Can Genetics Predict Treatment Response to a Computerized Self-help Program for Depression?

Genetic Predictors of Response to a Computerized Self-help Program for Depression

The goal of this project is to determine whether genetic information can be used to predict response to an internet-based treatment of depression. Several studies now indicate that completing an internet-based treatment for depression, called Deprexis, can significantly improve symptoms of depression. However, not everyone improves. The purpose of this study is to determine whether genetic profile can predict who is likely to improve.

Inclusion Criteria:

• English-speaking
• Have reliable access to the internet (i.e., dialup or broadband access)
• Be willing to donate saliva for DNA research
• Have a current symptoms of depression
• Be stable on medication and/or therapy (i.e. no changes within 2 weeks of study entry)

Exclusion Criteria:

• Any diagnosis of a psychotic or bipolar disorder
• Meeting for alcohol/drug dependence in the past year
• Having current suicidal risk warranting crisis intervention