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Pulmonary phage therapy to treat bacterial infections of the respiratory tract have been investigated in animals. The aim of the present study is to evaluate the efficacy of bacteriophages in infecting Pseudomonas aeruginosa (PA) strains present in sputum samples. A cocktail of 10 bacteriophages will be applied on 60 sputum samples obtained from cystic fibrosis (CF) patients during 6 hours.We will determine the bacteria and bacteriophages strains in sputum samples collected. Then the sensitivity of individual colony will be tested.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cystic fibrosis (CF) patients | Experimental | Cystic fibrosis patients whom induced sputum is collected in order to evaluate the efficacy of a cocktail of 10 bacteriophages. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Collection of induced sputum in order to evaluate the efficacy of a cocktail of 10 bacteriophages. | Other | Collection of induced sputum on cystic fibrosis patients in order to evaluate the efficacy of a cocktail of 10 bacteriophages. |
| Measure | Description | Time Frame |
|---|---|---|
| Pseudomonas aeruginosa (PA) strains counts after 6 hours in presence of bacteriophage | after 6 hours in presence of bacteriophage |
| Measure | Description | Time Frame |
|---|---|---|
| Pseudomonas aeruginosa (PA) strains counts after 24 hours in presence of bacteriophage | after 24 hours in presence of bacteriophage | |
| Bacteriophage counts after 6 hours incubation within sputum samples | after 6 hours incubation within sputum samples |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Raphaël RC CHIRON, RC | CHU de Montpellier - Hôpital Arnaud de Villeneuve | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Montpellier - Hôpital Arnaud de Villeneuve CRCM | Montpellier | Languedoc Roussillon | 34295 | France |
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| ID | Term |
|---|---|
| D003550 | Cystic Fibrosis |
| D011552 | Pseudomonas Infections |
| ID | Term |
|---|---|
| D010182 | Pancreatic Diseases |
| D004066 | Digestive System Diseases |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| Sensitivity of individual Pseudomonas aeruginosa (PA) colonies to bacteriophages | Sensitivity of individual PA colonies to bacteriophages |
| D030342 |
| Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D007232 | Infant, Newborn, Diseases |
| D016905 | Gram-Negative Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |