The Statins on Glucose Homeostasis in Subjects With Impaired Fasting Glucose

The Influence of Statins on Glucose Homeostasis and the Biomarkers of Diabetes in Subjects With Impaired Fasting Glucose

Evaluate the effects of rosuvastatin (maybe the highest diabetogenic) and pravastatin (seems to be protective) on the glucose homeostasis and other biomarkers in subjects with impaired fasting glucose.

Statin therapy effectively reduces cardiovascular events. However, trial data1 and meta-analyses suggest that statins also confer increased risk of development of diabetes. In order to elucidate whether statins increase risk of diabetes, investigators conducted this study to evaluate the effects of rosuvastatin (maybe the highest diabetogenic) and pravastatin (seems to be protective) on the glucose homeostasis and other biomarkers in subjects with impaired fasting glucose.

Inclusion Criteria:

1. Age 35-70 years old
2. Fasting blood glucose 100-125 mg/dL

Exclusion Criteria:

1. A1C >7.0%
2. 2hr glucose during OGTT >200 mg/dL
3. Total cholesterol >280 mg/dL
4. Previous diabetic history, coronary artery disease
5. Allergy to rosuvastatin or parvastatin
6. Baseline ALT more than 3 times UNL
7. Serum Cr > 2.0 mg/dL
8. Pregnancy, breast feeding or plan to be pregnant woman.