Hypoglycemia and Autonomic Nervous System Function

Hypoglycemia and Autonomic Nervous System Function

The goals of this proposal are to determine the effects of hypoglycemia on the autonomic nervous system.

Inclusion Criteria

• Healthy volunteers
• Males and females age 18 to 50 years

Exclusion Criteria

• Pregnancy
• Lactation
• Subjects who smoke or are on other forms of nicotine will be excluded
• Clinically evident coronary artery, cerebrovascular, or peripheral vascular disease, or presence of systemic illness that might affect autonomic function. Such illnesses include diabetes mellitus, congestive heart failure, hypertension, renal, pulmonary, hepatic disease, anemia, malignancies, untreated thyroid disease, and alcoholism.
• Current major depressive illness
• Any individuals on oral, injected, inhaled or topical corticosteroids within the last year or oral contraceptives within the past 3 months will be excluded.
• Use of medications other than thyroxine