Myeloproliferative Neoplasms and Bone Structure
Myeloproliferative Neoplasms and Bone Structure
This is a clinical study to evaluate the effect of CMPN (Chronic myeloproliferative neoplasm) to the bone.
The hypothesis is that patients with CMPN have a higher fracture-rate compared to the background population. We expect to find a lower BMD using conventional DXA scan (dual energy x-ray absorptiometry), and a change in other parameters using HR-pQCT (high-resolution peripheral quantitative computerized tomography).Biochemical bone markers is measured to support the hypothesis.
This is a clinical study to evaluate the effect of CMPN to the bone.
Three individual cohorts are defined; a cohort consisting of 50 patients with Polycythemia Vera (PV), a cohort consisting of 50 patients with Essential Thrombocythemia (ET), and a cohort consisting of 25 patients with Primary Myelofibrosis (PMF).
Patients are recruited from the Department of Hematology, Odense University Hospital.
Interventions consist of:
The outcome is compared to healthy control individuals.
Inclusion Criteria:
Exclusion Criteria:
mailtilsarah@yahoo.com+45 22324276
Hanne.Vestergaard@ouh.regionsyddanmark.dk+45 26258550