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| ID | Type | Description | Link |
|---|---|---|---|
| IRB201702171 | Other Identifier | University of Florida |
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The investigators are developing a test that is expected to measure the amount of radiation a patient has been exposed to after a nuclear bomb. The investigator will do this by measuring the DNA in the patients blood from cells killed by the radiation.
Many diseases and medical conditions can put DNA in the blood. The investigator needs to know how much DNA in order to better interpret our radiation detection test. Therefore, the investigator is collecting blood from several patients with different diseases or medical conditions and also healthy volunteers to measure their DNA content.
Patients that will be included in this study are pregnant women, patients who have suffered a pulmonary embolism within the past 48 hours, patients who have suffered from myocardial infarction in the past 48 hours, patients with autoimmune diseases and health patients.
The investigator will collect 8 mL (one and one half teaspoons) of blood one time only. The investigator may also collect the patient's past medical history, test results and disease treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pregnant Women | Females between the age of 18-80 who are pregnant One time blood draw to look at patient's DNA |
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| Pulmonary Embolism Patients | Male and Female patients that have suffered a pulmonary embolism within the past 48 hours One time blood draw to look at patient's DNA |
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| Myocardial Patients | Male and Female patients who have myocardial infarction in the past 48 hours. One time blood draw to look at patient's DNA |
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| Autoimmune Patients | Male and Female patients that have been diagnosed with an Autoimmune disease One time blood draw to look at patient's DNA |
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| Healthy Controls | Self-declared healthy adults (men and women). One time blood draw to look at patient's DNA |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| One time blood draw to look at patient's DNA | Other | One time blood draw to look at patient's DNA |
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| Measure | Description | Time Frame |
|---|---|---|
| Different diseases will be analysed for the levels of DNA circulating in the blood | To determine what medical conditions and disease states might increase circulating DNA levels at a magnitude similar to whole body irradiation. | blood will be tested up to 1 year after collection |
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Inclusion Criteria:
Patients must be adults in one of the following categories:
Patients must be willing to undergo a blood draw
Patients must provide study-specific informed consent prior to study entry
Exclusion Criteria:
1. Patients not meeting the above inclusion criteria
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Seeking healthy volunteers, pregnant women, patients who recently suffered a heart attach or pulmonary embolism, and patiebts with autoimmune disease. Patients who are health individuals will also be asked to participate.
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| Name | Affiliation | Role |
|---|---|---|
| Paul Okunieff, MD | University of Florida | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shands Davis Cancer Center | Gainesville | Florida | 32610 | United States |
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| ID | Term |
|---|---|
| D011655 | Pulmonary Embolism |
| D009203 | Myocardial Infarction |
| D001327 | Autoimmune Diseases |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D004617 | Embolism |
| D016769 | Embolism and Thrombosis |
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4-5 ml of blood will be processed and the plasma will be divided into 150 μl aliquots
| D014652 |
| Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
| D007154 | Immune System Diseases |