Treatment With Botulinum Toxin Type A (BOTOX®) in Chinese Patients With Moderate to Severe Frown Lines

A study to evaluate safety and efficacy of treatment with botulinum toxin Type A (BOTOX®) in Chinese patients with moderate to severe frown lines (Glabellar Rhytides) previously treated with facial laser resurfacing.

Inclusion Criteria:

• moderate or severe frown lines
• facial laser treatment between 4 to 8 weeks prior to Day 1

Exclusion Criteria:

• previous use of botulinum toxin for any indication
• diagnosis of myasthenia gravis, Eaton-Lambert syndrome, amyotrophic lateral sclerosis
• microdermabrasion or superficial peels, permanent make-up to the brow and forehead area within the last 3 months
• facial cosmetic procedures within the last 6 Months
• treatment to forehead, brow, nose or midface areas with any filler within the last 12 months
• use of a new topical skin care product within 1 month of the screening
• any prior forehead or periorbital surgery or brow lift
• deep dermal scarring, excessively thick sebaceous skin, and/ or loss of skin elasticity
• any facial skin infection or unhealed skin lesion
• pregnant or breast-feeding