Hyper-CVAD Treatment in Lymphoblastic Lymphoma

The Clinical Outcomes of Hyper-CVAD Treatment in Lymphoblastic Lymphoma

Treatment outcomes of lymphoblastic lymphoma (LBL) have improved by the use of the regimens for acute lymphoblastic leukemia. Hyper-CVAD is one of the most effective treatments with high remission rate in acute lymphoblastic leukemia (ALL) and LBL. However, the treatment outcome of hyper-CVAD in LBL has reported only in small number of patients from single institution. The investigators conducted this study to evaluate the hyper-CVAD regimen based treatment in LBL.

We will analyze treatment outcome of lymphoblastic lymphoma patients treated with hyper-CVAD regimen from 13 institutions in Korea. In all patients, hyper-CVAD was initial treatment. After achievement of response, patients either underwent hematopoietic stem cell transplantation (HSCT) or consolidation with hyper-CVAD.

Inclusion Criteria:

• age over 18 at diagnosis
• Pathologically proven lymphoblastic lymphoma

Exclusion Criteria:

• proven HIV infection
• pretreatment with other regimens