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Oral sucrose reduces pain during heel sticks and venipunctures in preterm infants. The purpose of this study was to determine the effectiveness of local anesthetic eye drops and a pacifier, plus repeated doses of 24% sucrose, to relieve pain associated with eye examinations for retinopathy of prematurity.
Oral sucrose reduces pain during heel sticks and venipunctures in preterm infants. Administration of oral sucrose with and without non-nutritive sucking is the most frequently studied non-pharmacological intervention for procedural pain relief in neonates.The purpose of this study was to determine the effectiveness of local anesthetic eye drops and a pacifier, plus repeated doses of 24% sucrose, to relieve pain associated with eye examinations for retinopathy of prematurity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| oral sucrose solution | Active Comparator | local anesthetic eye drops (Alcaine 0.5% drop) and a pacifier, plus 0.5 cc/kg of 24% sucrose, to relieve pain associated with eye examinations for retinopathy of prematurity will be given |
|
| steril water | Placebo Comparator | steril water 0,5 cc/kg plus topical anesthetics (Alcaine %0.5 damla) before eye examination will be given |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oral sucrose solution | Dietary Supplement | Oral sucrose solution plus topical anesthetics |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Premature Infant Pain Profile | Premature Infant Pain Profile were determined after each eye examination | two hours |
| Measure | Description | Time Frame |
|---|---|---|
| Crying time | Crying time will be determined after each eye examination | two hours |
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Inclusion Criteria:
-VLBW infants <32 weeks of gestational age
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Eda Ç İlarslan, MD | MD | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dr Sami Ulus Children Hospital | Ankara | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23440783 | Background | Stevens B, Yamada J, Lee GY, Ohlsson A. Sucrose for analgesia in newborn infants undergoing painful procedures. Cochrane Database Syst Rev. 2013 Jan 31;(1):CD001069. doi: 10.1002/14651858.CD001069.pub4. | |
| 24730361 | Derived | Dilli D, Ilarslan NE, Kabatas EU, Zenciroglu A, Simsek Y, Okumus N. Oral sucrose and non-nutritive sucking goes some way to reducing pain during retinopathy of prematurity eye examinations. Acta Paediatr. 2014 Feb;103(2):e76-9. doi: 10.1111/apa.12454. Epub 2013 Nov 11. |
| Label | URL |
|---|---|
| http://www.ncbi.nlm.nih.gov/pubmed/23440783 | View source |
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| Steril water |
| Dietary Supplement |
steril water plus topical anesthetics |
|