Dexamethasone Reduces Postoperative Emesis by Decreasing PGF2α and LTC4 Levels

Dexamethasone Reduces Postoperative Emesis by Decreasing PGF2α and LTC4 Levels

Hypothesis: Dexamethasone reduces postoperative emesis in thyroidectomy and mastectomy patients.

This study has been done to further study the effectiveness of dexamethasone in the prevention of postoperative emesis after breast and thyroid surgery and at the same time, the mechanism of action was investigated. In this prospective, randomized controlled trial it was hypothesized that corticosteroids exert their antiemetic effects in postoperative period via plasma prostaglandin F2 alpha (PGF2 α) and plasma leukotriene C4 (LTC4) inhibition.

Inclusion Criteria:

• breast and thyroid cancer patients no neoadjuvant treated no NSAID or steroid usage heallthy volunteers, signed the informed consent

Exclusion Criteria:

• ones who did not sign the consent form NSAID or steroid users