Prophylaxis Versus on Demand Treatment for Children With Hemophilia A

Routine Prophylaxis Treatment Versus On-demand Treatment for Children With Severe Hemophilia A: Comparison of All Bleeding Events in Chinese Hemophilia Patients

Comparison of the effect of three times a week prophylaxis on all bleeds with on-demand treatment for children with severe Hemophilia A.

Inclusion Criteria:

• Male, aged 2-16yrs
• Severe hemophilia A (<1% FVIII:C [Blood Clotting Factor VIII:C] )
• Minimum of at least 50 documented ED (exposure day) prior to enrolment
• No measurable inhibitor activity at baseline and history of FVIII inhibitor antibody formation
• Parents or legal guardians document, sign, and date informed consent

Exclusion Criteria:

• Another bleeding disease that is different from hemophilia A
• Known hypersensitivity to the active substance, mouse or hamster protein
• Thrombocytopenia (platelet count <100 000/mm3) based on previous medical records