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This is prospective, randomized, multicenter, multinational, randomized (1:1) study. The aim of this study is to assess the importance of functional assessment of coronary artery disease prior to bypass surgery. In particular, an FFR-guided strategy will be compared to the traditional Angio-guided strategy in the guidance of surgical revascularization by aorto-coronary bypass grafting.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Angio-guided arm | Active Comparator | In this arm will be included the patient randomized to a Angiography-guided surgical revascularization strategy. |
|
| FFR-guided arm | Experimental | In this arm will be included the patient randomized to a FFR-guided surgical revascularization strategy. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Surgical revascularization | Procedure | The final intervention (surgical revascularization) will be the same for both arms. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Rate of occluded bypass grafts | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| a) Lenght of hospital stay; b) Changes in surgical strategy: i.e. open-chest surgery vs. mini-thoracotomy; extensive surgery versus minimal invasive approaches. | participants will be followed for the duration of hospital stay, an expected average of 3-4 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Emanuele Barbato, MD, PhD | Contact | emanuele.barbato@olvz-aalst.be |
| Name | Affiliation | Role |
|---|---|---|
| Emanuele Barbato, MD, PhD | Cardiovascular Center Aalst, OLV Hospital, Aalst (Belgium) | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cardiovascular Center Aalst OLV Hospital | Recruiting | Aalst | 9300 | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31270037 | Derived | Toth GG, De Bruyne B, Kala P, Ribichini FL, Casselman F, Ramos R, Piroth Z, Fournier S, Piccoli A, Van Mieghem C, Penicka M, Mates M, Nemec P, Van Praet F, Stockman B, Degriek I, Barbato E. Graft patency after FFR-guided versus angiography-guided coronary artery bypass grafting: the GRAFFITI trial. EuroIntervention. 2019 Dec 6;15(11):e999-e1005. doi: 10.4244/EIJ-D-19-00463. | |
| 30027499 |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| Department of Internal Medicine and Cardiology, University Hospital Brno | Not yet recruiting | Brno | Czechia |
|
| Hungarian Institute of Cardiology | Not yet recruiting | Budapest | Hungary |
|
| Derived |
| Toth GG, De Bruyne B, Kala P, Ribichini FL, Casselman F, Ramos R, Piroth Z, Fournier S, Van Mieghem C, Penicka M, Mates M, Van Praet F, Degriek I, Barbato E. Study Design of the Graft Patency After FFR-Guided Versus Angiography-Guided CABG Trial (GRAFFITI). J Cardiovasc Transl Res. 2018 Aug;11(4):269-273. doi: 10.1007/s12265-018-9818-9. Epub 2018 Jul 19. |
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |