Graft Patency After FFR-guided Versus Angio-guided CABG (GRAFFITI) Trial

Graft Patency After FFR-guided Versus Angio-guided CABG: a Prospective, Multicenter, Multinational, Randomized (1:1) Controlled Trial

This is prospective, randomized, multicenter, multinational, randomized (1:1) study. The aim of this study is to assess the importance of functional assessment of coronary artery disease prior to bypass surgery. In particular, an FFR-guided strategy will be compared to the traditional Angio-guided strategy in the guidance of surgical revascularization by aorto-coronary bypass grafting.

Inclusion Criteria:

• Patients with stable angina, unstable angina or NSTEMI candidate to CABG
• Significant LAD and/or LM lesion - proved by FFR or Angiography AND
• At least one more, angiographycally intermediate lesion

Exclusion Criteria:

• Significant valvular disease with indication to surgical replacement
• Severe left ventricular dysfunction (EF<35%)
• Acute STEMI
• Atrial fibrillation, if Maze procedure is planned