S1216, Phase III ADT+TAK-700 vs. ADT+Bicalutamide for Metastatic Prostate Cancer | NCT01809691 | Trialant

S1216, Phase III ADT+TAK-700 vs. ADT+Bicalutamide for Metastatic Prostate Cancer | NCT01809691 | Trialant

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: Male
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion Criteria:

Clinical diagnosis of metastatic prostate cancer.

Serum testosterone within institutional limits of normal.

PSA ≥ 2 ng/mL within 90 days prior to initiation of androgen deprivation. therapy (for early induction) or prior to registration (for late induction).

DEXA scan within 2 years prior to registration.

ECG within 42 days prior to registration and QTc interval ≤ 460 msec.

LVEF within 42 days prior to registration and within institutional limits of normal.

Adequate hepatic function as evidenced by bilirubin ≤ 2 x institutional upper limit of normal (ULN), SGOT (AST) and SGPT (ALT) ≤ 3 x institutional ULN, or ≤ 5 x institutional ULN if liver metastases are present.

Adequate renal function as evidenced by calculated creatinine clearance ≥ 40 mL/min.

Adequate hematologic function as evidenced by leukocytes ≥ 3,000/mcL, absolute neutrophil count (ANC) ≥ 1,500/mcL, hemoglobin ≥ 9 g/dL, and platelets ≥ 100,000/mcL.

Zubrod performance status of 0 - 2. Zubrod performance status 3 will be allowed if from bone pain only.

≥ 18 years of age.

Men of reproduction potential and those who are surgically sterilized (i.e., postvasectomy) must agree to practice effective barrier contraception or agree to abstain from intercourse while receiving treatment on this study and for at least 4 months after protocol treatment ends.

Exclusion Criteria:

Known brain metastases.

No more than 36 months of prior neoadjuvant and/or adjuvant hormonal therapy.

≥ 6 months since completion of androgen deprivation therapy.

Prior or concurrent therapy with ketoconazole, aminoglutethimide or abiraterone acetate, or enzalutamide (MDV3100). Concurrent megestrol for hot flashes is allowed.

Prior chemotherapy for treatment of metastatic prostate cancer. Prior chemotherapy in the neoadjuvant or adjuvant setting is allowed.

≥ 2 years since completion of chemotherapy in the neoadjuvant or adjuvant setting.

Concurrent use of experimental therapy is not allowed.

≥ 30 days since prior medical castration for metastatic prostate cancer.

If method of castration is a LHRH agonist, the patient must be willing to continue the use of LHRH and add bicalutamide or TAK-700 during protocol treatment.

If the patient was on an antiandrogen (e.g. bicalutamide, flutamide), the patient must be willing to switch over to bicalutamide or TAK-700 (according to randomization).

Prior bilateral orchiectomy.

Concurrent use of LHRH antagonists (e.g. Degarelix)

Grade III/IV cardiac disease (as defined by the NYHA Criteria), thromboembolic event, unstable angina pectoris, myocardial infarction within 6 months, or serious uncontrolled cardiac arrhythmia.

Uncontrolled hypertension (defined as blood pressure > 160 mmHg systolic and > 90 mmHg diastolic at 2 separate measurements no more than 60 minutes apart during the Screening visit) despite appropriate medical therapy.

Known human immunodeficiency virus (HIV)infection, active chronic hepatitis B or C, life-threatening illness unrelated to cancer, or any serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with participation in this study.

History of primary and secondary adrenal insufficiency.

Hypersensitivity to TAK-700, to TAK-700 metabolites, to bicalutamide, or to LHRH agonists.

Gastrointestinal (GI) disease or GI procedure that could interfere with the GI absorption or tolerance of TAK-700, including difficulty swallowing oral medications.

No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, adequately treated Stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease-free for 5 years.

Veterans Administration Medical Center - Birmingham

Birmingham, Alabama 35233, United States

University of Arizona Cancer Center at Saint Joseph's

Phoenix, Arizona 85004, United States

University of Arizona Cancer Center-Orange Grove Campus

Tucson, Arizona 85704, United States

University of Arizona Cancer Center-North Campus

Tucson, Arizona 85719, United States

Southern Arizona Veterans Affairs Health Center

Tucson, Arizona 85723, United States

The University of Arizona Medical Center-University Campus

Tucson, Arizona 85724, United States

Fowler Family Center for Cancer Care

Jonesboro, Arkansas 72401, United States

Veteran's Administration Medical Center

Little Rock, Arkansas 72205, United States

Kaiser Permanente-Deer Valley Medical Center

Antioch, California 94531, United States

Sutter Auburn Faith Hospital

Auburn, California 95602, United States

AIS Cancer Center at San Joaquin Community Hospital

Bakersfield, California 93301, United States

Alta Bates Summit Medical Center-Herrick Campus

Berkeley, California 94704, United States

Mills - Peninsula Hospitals

Burlingame, California 94010, United States

City of Hope Corona

Corona, California 92879, United States

Sutter Davis Hospital

Davis, California 95616, United States

City of Hope Comprehensive Cancer Center

Duarte, California 91010, United States

Kaiser Permanente-Fremont

Fremont, California 94538, United States

University Oncology Associates

Fresno, California 93701, United States

Kaiser Permanente

Fresno, California 93720, United States

UC San Diego Moores Cancer Center

La Jolla, California 92093, United States

Loma Linda University Medical Center

Loma Linda, California 92354, United States

Veterans Affairs Loma Linda Healthcare System

Loma Linda, California 92357, United States

Los Angeles County-USC Medical Center

Los Angeles, California 90033, United States

USC / Norris Comprehensive Cancer Center

Los Angeles, California 90033, United States

Fremont - Rideout Cancer Center

Marysville, California 95901, United States

Mather Veteran Affairs Medical Center

Mather, California 95655, United States

Mercy UC Davis Cancer Center

Merced, California 95340, United States

Memorial Medical Center

Modesto, California 95355, United States

Kaiser Permanente-Modesto

Modesto, California 95356, United States

Palo Alto Medical Foundation-Camino Division

Mountain View, California 94040, United States

Palo Alto Medical Foundation-Gynecologic Oncology

Mountain View, California 94040, United States

USC Norris Oncology/Hematology-Newport Beach

Newport Beach, California 92663, United States

Sutter Cancer Research Consortium

Novato, California 94945, United States

Kaiser Permanente-Oakland

Oakland, California 94611, United States

UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California 92868, United States

Palo Alto Medical Foundation Health Care

Palo Alto, California 94301, United States

Keck Medical Center of USC Pasadena

Pasadena, California 91105, United States

PCR Oncology

Pismo Beach, California 93449, United States

Kaiser Permanente-Redwood City

Redwood City, California 94063, United States

Kaiser Permanente-Richmond

Richmond, California 94801, United States

Kaiser Permanente-Roseville

Roseville, California 95661, United States

Sutter Roseville Medical Center

Roseville, California 95661, United States

Sutter General Hospital

Sacramento, California 95816, United States

University of California Davis Comprehensive Cancer Center

Sacramento, California 95817, United States

Kaiser Permanente-South Sacramento

Sacramento, California 95823, United States

Kaiser Permanente - Sacramento

Sacramento, California 95825, United States

California Pacific Medical Center-Pacific Campus

San Francisco, California 94115, United States

Kaiser Permanente-San Francisco

San Francisco, California 94115, United States

UCSF Medical Center-Mount Zion

San Francisco, California 94115, United States

UCSF Medical Center-Mission Bay

San Francisco, California 94158, United States

Kaiser Permanente-Santa Teresa-San Jose

San Jose, California 95119, United States

Kaiser Permanente San Leandro

San Leandro, California 94577, United States

Kaiser Permanente-San Rafael

San Rafael, California 94903, United States

Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California 95051, United States

Palo Alto Medical Foundation-Santa Cruz

Santa Cruz, California 95065, United States

Kaiser Permanente-Santa Rosa

Santa Rosa, California 95403, United States

Sutter Pacific Medical Foundation

Santa Rosa, California 95403, United States

Kaiser Permanente-South San Francisco

South San Francisco, California 94080, United States

Kaiser Permanente-Stockton

Stockton, California 95210, United States

Palo Alto Medical Foundation-Sunnyvale

Sunnyvale, California 94086, United States

Gene Upshaw Memorial Tahoe Forest Cancer Center

Truckee, California 96161, United States

Northbay Cancer Center

Vacaville, California 95687, United States

Kaiser Permanente Medical Center-Vacaville

Vacaville, California 95688, United States

Kaiser Permanente-Vallejo

Vallejo, California 94589, United States

Sutter Solano Medical Center/Cancer Center

Vallejo, California 94589, United States

Kaiser Permanente-Walnut Creek

Walnut Creek, California 94596, United States

Rocky Mountain Cancer Centers-Aurora

Aurora, Colorado 80012, United States

The Medical Center of Aurora

Aurora, Colorado 80012, United States

University of Colorado Cancer Center - Anschutz Cancer Pavilion

Aurora, Colorado 80045, United States

Boulder Community Hospital

Boulder, Colorado 80301, United States

Rocky Mountain Cancer Centers-Boulder

Boulder, Colorado 80304, United States

Penrose-Saint Francis Healthcare

Colorado Springs, Colorado 80907, United States

Rocky Mountain Cancer Centers-Penrose

Colorado Springs, Colorado 80907, United States

Porter Adventist Hospital

Denver, Colorado 80210, United States

Colorado Blood Cancer Institute

Denver, Colorado 80218, United States

Presbyterian - Saint Lukes Medical Center - Health One

Denver, Colorado 80218, United States

Rocky Mountain Cancer Centers-Midtown

Denver, Colorado 80218, United States

SCL Health Saint Joseph Hospital

Denver, Colorado 80218, United States

Rocky Mountain Cancer Centers-Rose

Denver, Colorado 80220, United States

Rose Medical Center

Denver, Colorado 80220, United States

Colorado Cancer Research Program NCORP

Denver, Colorado 80222, United States

Mercy Medical Center

Durango, Colorado 81301, United States

Southwest Oncology PC

Durango, Colorado 81301, United States

Comprehensive Cancer Care and Research Institute of Colorado LLC

Englewood, Colorado 80113, United States

Swedish Medical Center

Englewood, Colorado 80113, United States

Mountain Blue Cancer Care Center

Golden, Colorado 80401, United States

North Colorado Medical Center

Greeley, Colorado 80631, United States

Rocky Mountain Cancer Centers-Greenwood Village

Greenwood Village, Colorado 80111, United States

Rocky Mountain Cancer Centers-Lakewood

Lakewood, Colorado 80228, United States

Saint Anthony Hospital

Lakewood, Colorado 80228, United States

Rocky Mountain Cancer Centers-Littleton

Littleton, Colorado 80120, United States

Littleton Adventist Hospital

Littleton, Colorado 80122, United States

Rocky Mountain Cancer Centers-Sky Ridge

Lone Tree, Colorado 80124, United States

Sky Ridge Medical Center

Lone Tree, Colorado 80124, United States

Longmont United Hospital

Longmont, Colorado 80501, United States

Rocky Mountain Cancer Centers-Longmont

Longmont, Colorado 80501, United States

McKee Medical Center

Loveland, Colorado 80539, United States

Parker Adventist Hospital

Parker, Colorado 80138, United States

Rocky Mountain Cancer Centers-Parker

Parker, Colorado 80138, United States

Saint Mary Corwin Medical Center

Pueblo, Colorado 81004, United States

Rocky Mountain Cancer Centers - Pueblo

Pueblo, Colorado 81008, United States

Rocky Mountain Cancer Centers-Thornton

Thornton, Colorado 80260, United States

SCL Health Lutheran Medical Center

Wheat Ridge, Colorado 80033, United States

Greenwich Hospital

Greenwich, Connecticut 06830, United States

Yale University

New Haven, Connecticut 06520, United States

Eastern Connecticut Hematology and Oncology Associates

Norwich, Connecticut 06360, United States

Stamford Hospital/Bennett Cancer Center

Stamford, Connecticut 06904, United States

Beebe Medical Center

Lewes, Delaware 19958, United States

Medical Oncology Hematology Consultants PA

Newark, Delaware 19713, United States

Regional Hematology and Oncology PA

Newark, Delaware 19713, United States

Christiana Care Health System-Christiana Hospital

Newark, Delaware 19718, United States

Nanticoke Memorial Hospital

Seaford, Delaware 19973, United States

MedStar Georgetown University Hospital

Washington D.C., District of Columbia 20007, United States

MedStar Washington Hospital Center

Washington D.C., District of Columbia 20010, United States

Sibley Memorial Hospital

Washington D.C., District of Columbia 20016, United States

George Washington University Medical Center

Washington D.C., District of Columbia 20037, United States

Veterans Affairs Medical Center -Washington DC

Washington D.C., District of Columbia 20422, United States

Broward Health Medical Center

Fort Lauderdale, Florida 33316, United States

Lakeland Regional Health Hollis Cancer Center

Lakeland, Florida 33805, United States

Florida Hospital Orlando

Orlando, Florida 32803, United States

UF Cancer Center at Orlando Health

Orlando, Florida 32806, United States

Moffitt Cancer Center

Tampa, Florida 33612, United States

John B Amos Cancer Center

Columbus, Georgia 31904, United States

Atlanta VA Medical Center

Decatur, Georgia 30033, United States

Northeast Georgia Medical Center-Gainesville

Gainesville, Georgia 30501, United States

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia 31405, United States

Hawaii Cancer Care Inc-POB II

Honolulu, Hawaii 96813, United States

Queen's Medical Center

Honolulu, Hawaii 96813, United States

University of Hawaii Cancer Center

Honolulu, Hawaii 96813, United States

Hawaii Cancer Care Inc-Liliha

Honolulu, Hawaii 96817, United States

Hawaii Oncology Inc-Kuakini

Honolulu, Hawaii 96817, United States

Kaiser Permanente Moanalua Medical Center

Honolulu, Hawaii 96819, United States

Tripler Army Medical Center

Honolulu, Hawaii 96859, United States

Hawaii Oncology Inc-Pali Momi

‘Aiea, Hawaii 96701, United States

Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho 83706, United States

Kootenai Medical Center

Coeur d'Alene, Idaho 83814, United States

Kootenai Cancer Center

Post Falls, Idaho 83854, United States

Kootenai Cancer Clinic

Sandpoint, Idaho 83864, United States

Rush - Copley Medical Center

Aurora, Illinois 60504, United States

Saint Joseph Medical Center

Bloomington, Illinois 61701, United States

Illinois CancerCare-Bloomington

Bloomington, Illinois 61704, United States

Illinois CancerCare-Canton

Canton, Illinois 61520, United States

Illinois CancerCare-Carthage

Carthage, Illinois 62321, United States

Centralia Oncology Clinic

Centralia, Illinois 62801, United States

Mount Sinai Hospital Medical Center

Chicago, Illinois 60608, United States

Northwestern University

Chicago, Illinois 60611, United States

University of Chicago Comprehensive Cancer Center

Chicago, Illinois 60637, United States

Weiss Memorial Hospital

Chicago, Illinois 60640, United States

Presence Saint Joseph Hospital-Chicago

Chicago, Illinois 60657, United States

Cancer Care Center of Decatur

Decatur, Illinois 62526, United States

Decatur Memorial Hospital

Decatur, Illinois 62526, United States

Heartland Cancer Research NCORP

Decatur, Illinois 62526, United States

Crossroads Cancer Center

Effingham, Illinois 62401, United States

Illinois CancerCare-Eureka

Eureka, Illinois 61530, United States

NorthShore University HealthSystem-Evanston Hospital

Evanston, Illinois 60201, United States

Illinois CancerCare-Galesburg

Galesburg, Illinois 61401, United States

Northwestern Medicine Cancer Center Delnor

Geneva, Illinois 60134, United States

NorthShore University HealthSystem-Glenbrook Hospital

Glenview, Illinois 60026, United States

NorthShore University HealthSystem-Highland Park Hospital

Highland Park, Illinois 60035, United States

Hines Veterans Administration Hospital

Hines, Illinois 60141, United States

Joliet Oncology-Hematology Associates Limited

Joliet, Illinois 60435, United States

Presence Saint Mary's Hospital

Kankakee, Illinois 60901, United States

Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois 61443, United States

Illinois CancerCare-Macomb

Macomb, Illinois 61455, United States

Loyola University Medical Center

Maywood, Illinois 60153, United States

Trinity Medical Center

Moline, Illinois 61265, United States

Illinois CancerCare-Monmouth

Monmouth, Illinois 61462, United States

Community Cancer Center Foundation

Normal, Illinois 61761, United States

Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois 61350, United States

Ottawa Regional Hospital and Healthcare Center

Ottawa, Illinois 61350, United States

Illinois CancerCare-Pekin

Pekin, Illinois 61554, United States

OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center

Pekin, Illinois 61554, United States

Methodist Medical Center of Illinois

Peoria, Illinois 61603, United States

Proctor Hospital

Peoria, Illinois 61614, United States

Illinois CancerCare-Peoria

Peoria, Illinois 61615, United States

OSF Saint Francis Medical Center

Peoria, Illinois 61637, United States

Illinois CancerCare-Peru

Peru, Illinois 61354, United States

Illinois CancerCare-Princeton

Princeton, Illinois 61356, United States

West Suburban Medical Center

River Forest, Illinois 60305, United States

SwedishAmerican Regional Cancer Center/ACT

Rockford, Illinois 61114, United States

Southern Illinois University School of Medicine

Springfield, Illinois 62702, United States

Springfield Clinic

Springfield, Illinois 62702, United States

Memorial Medical Center

Springfield, Illinois 62781, United States

Cancer Care Specialists of Illinois-Swansea

Swansea, Illinois 62226, United States

Carle Cancer Center

Urbana, Illinois 61801, United States

Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois 60555, United States

Rush-Copley Healthcare Center

Yorkville, Illinois 60560, United States

IU Health Bloomington

Bloomington, Indiana 47403, United States

Memorial Regional Cancer Center Day Road

Mishawaka, Indiana 46545, United States

Memorial Hospital of South Bend

South Bend, Indiana 46601, United States

Porter Memorial Hospital

Valparaiso, Indiana 46383, United States

McFarland Clinic PC-William R Bliss Cancer Center

Ames, Iowa 50010, United States

Mercy Hospital

Cedar Rapids, Iowa 52403, United States

Oncology Associates at Mercy Medical Center

Cedar Rapids, Iowa 52403, United States

Medical Oncology and Hematology Associates-West Des Moines

Clive, Iowa 50325, United States

Alegent Health Mercy Hospital

Council Bluffs, Iowa 51503, United States

Genesis Medical Center - East Campus

Davenport, Iowa 52803, United States

Medical Oncology and Hematology Associates-Laurel

Des Moines, Iowa 50314, United States

Mercy Medical Center - Des Moines

Des Moines, Iowa 50314, United States

University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa 52242, United States

Iowa City VA Healthcare System

Iowa City, Iowa 52246, United States

Cancer Center of Kansas - Chanute

Chanute, Kansas 66720, United States

Cancer Center of Kansas - Dodge City

Dodge City, Kansas 67801, United States

Cancer Center of Kansas - El Dorado

El Dorado, Kansas 67042, United States

Cancer Center of Kansas - Fort Scott

Fort Scott, Kansas 66701, United States

Saint Catherine Hospital

Garden City, Kansas 67846, United States

Heartland Cancer Center

Great Bend, Kansas 67530, United States

Saint Rose Ambulatory and Surgery Center

Great Bend, Kansas 67530, United States

Hays Medical Center

Hays, Kansas 67601, United States

Cancer Center of Kansas-Independence

Independence, Kansas 67301, United States

University of Kansas Cancer Center-West

Kansas City, Kansas 66112, United States

University of Kansas Cancer Center

Kansas City, Kansas 66160, United States

Cancer Center of Kansas-Kingman

Kingman, Kansas 67068, United States

Lawrence Memorial Hospital

Lawrence, Kansas 66044, United States

Cancer Center of Kansas-Liberal

Liberal, Kansas 67905, United States

Cancer Center of Kansas-Manhattan

Manhattan, Kansas 66502, United States

Cancer Center of Kansas - McPherson

McPherson, Kansas 67460, United States

Cancer Center of Kansas - Newton

Newton, Kansas 67114, United States

Olathe Medical Center

Olathe, Kansas 66061, United States

Menorah Medical Center

Overland Park, Kansas 66209, United States

University of Kansas Cancer Center-Overland Park

Overland Park, Kansas 66210, United States

Cancer Center of Kansas - Parsons

Parsons, Kansas 67357, United States

Cancer Center of Kansas - Pratt

Pratt, Kansas 67124, United States

Cancer Center of Kansas - Salina

Salina, Kansas 67401, United States

Salina Regional Health Center

Salina, Kansas 67401, United States

Cotton O'Neil Cancer Center / Stormont Vail Health

Topeka, Kansas 66606, United States

Saint Francis Hospital and Medical Center - Topeka

Topeka, Kansas 66606, United States

Topeka VA Hospital

Topeka, Kansas 66622, United States

Cancer Center of Kansas - Wellington

Wellington, Kansas 67152, United States

Associates In Womens Health

Wichita, Kansas 67208, United States

Cancer Center of Kansas-Wichita Medical Arts Tower

Wichita, Kansas 67208, United States

Cancer Center of Kansas - Wichita

Wichita, Kansas 67214, United States

Via Christi Regional Medical Center

Wichita, Kansas 67214, United States

Wichita NCI Community Oncology Research Program

Wichita, Kansas 67214, United States

Cancer Center of Kansas - Winfield

Winfield, Kansas 67156, United States

University of Kentucky/Markey Cancer Center

Lexington, Kentucky 40536, United States

Hematology/Oncology Clinic LLP

Baton Rouge, Louisiana 70809, United States

Ochsner Health Center-Summa

Baton Rouge, Louisiana 70809, United States

Ochsner Medical Center Kenner

Kenner, Louisiana 70065, United States

East Jefferson General Hospital

Metairie, Louisiana 70006, United States

Louisiana State University Health Science Center

New Orleans, Louisiana 70112, United States

Tulane University Health Sciences Center

New Orleans, Louisiana 70112, United States

University Medical Center New Orleans

New Orleans, Louisiana 70112, United States

Ochsner Medical Center Jefferson

New Orleans, Louisiana 70121, United States

Harold Alfond Center for Cancer Care

Augusta, Maine 04330, United States

Eastern Maine Medical Center

Bangor, Maine 04401, United States

Penobscot Bay Medical Center

Rockport, Maine 04856, United States

Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland 21287, United States

Montgomery General Hospital-Olney

Olney, Maryland 20832, United States

Boston Medical Center

Boston, Massachusetts 02118, United States

Dana-Farber Cancer Institute

Boston, Massachusetts 02215, United States

Steward Saint Elizabeth's Medical Center

Brighton, Massachusetts 02135, United States

Lahey Hospital and Medical Center

Burlington, Massachusetts 01805, United States

Dana Farber Community Cancer Care-Quincy

Quincy, Massachusetts 02169, United States

Hickman Cancer Center

Adrian, Michigan 49221, United States

Saint Joseph Mercy Hospital

Ann Arbor, Michigan 48106-0995, United States

Michigan Cancer Research Consortium NCORP

Ann Arbor, Michigan 48106, United States

University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan 48109, United States

Bronson Battle Creek

Battle Creek, Michigan 49017, United States

IHA Hematology Oncology Consultants-Brighton

Brighton, Michigan 48114, United States

Saint Joseph Mercy Brighton

Brighton, Michigan 48114, United States

IHA Hematology Oncology Consultants-Canton

Canton, Michigan 48188, United States

Saint Joseph Mercy Canton Health Center

Canton, Michigan 48188, United States

IHA Hematology Oncology Consultants-Chelsea

Chelsea, Michigan 48118, United States

Saint Joseph Mercy Chelsea

Chelsea, Michigan 48118, United States

Saint John Hospital and Medical Center

Detroit, Michigan 48236, United States

Green Bay Oncology - Escanaba

Escanaba, Michigan 49829, United States

Botsford General Hospital

Farmington, Michigan 48334, United States

Cancer Research Consortium of West Michigan NCORP

Grand Rapids, Michigan 49503, United States

Mercy Health Saint Mary's

Grand Rapids, Michigan 49503, United States

Spectrum Health at Butterworth Campus

Grand Rapids, Michigan 49503, United States

Green Bay Oncology - Iron Mountain

Iron Mountain, Michigan 49801, United States

West Michigan Cancer Center

Kalamazoo, Michigan 49007, United States

Sparrow Hospital

Lansing, Michigan 48912, United States

Mercy Health Mercy Campus

Muskegon, Michigan 49444, United States

Lakeland Community Hospital

Niles, Michigan 49120, United States

Saint Joseph Mercy Oakland

Pontiac, Michigan 48341, United States

Lake Huron Medical Center

Port Huron, Michigan 48060, United States

Spectrum Health Reed City Hospital

Reed City, Michigan 49677, United States

William Beaumont Hospital-Royal Oak

Royal Oak, Michigan 48073, United States

Saint Mary's of Michigan

Saginaw, Michigan 48601, United States

Marie Yeager Cancer Center

Saint Joseph, Michigan 49085, United States

Munson Medical Center

Traverse City, Michigan 49684, United States

William Beaumont Hospital - Troy

Troy, Michigan 48098, United States

Saint John Macomb-Oakland Hospital

Warren, Michigan 48093, United States

IHA Hematology Oncology Consultants-Ann Arbor

Ypsilanti, Michigan 48197, United States

Sanford Clinic North-Bemidgi

Bemidji, Minnesota 56601, United States

Fairview Ridges Hospital

Burnsville, Minnesota 55337, United States

Mercy Hospital

Coon Rapids, Minnesota 55433, United States

Essentia Health Cancer Center

Duluth, Minnesota 55805, United States

Fairview-Southdale Hospital

Edina, Minnesota 55435, United States

Lake Region Healthcare Corporation-Cancer Care

Fergus Falls, Minnesota 56537, United States

Unity Hospital

Fridley, Minnesota 55432, United States

Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota 55109, United States

Saint John's Hospital - Healtheast

Maplewood, Minnesota 55109, United States

Abbott-Northwestern Hospital

Minneapolis, Minnesota 55407, United States

Hennepin County Medical Center

Minneapolis, Minnesota 55415, United States

Minneapolis Veterans Medical Center

Minneapolis, Minnesota 55417, United States

Health Partners Inc

Minneapolis, Minnesota 55454, United States

University of Minnesota/Masonic Cancer Center

Minneapolis, Minnesota 55455, United States

North Memorial Medical Health Center

Robbinsdale, Minnesota 55422, United States

Mayo Clinic

Rochester, Minnesota 55905, United States

Coborn Cancer Center at Saint Cloud Hospital

Saint Cloud, Minnesota 56303, United States

Metro Minnesota Community Oncology Research Consortium

Saint Louis Park, Minnesota 55416, United States

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota 55416, United States

Regions Hospital

Saint Paul, Minnesota 55101, United States

United Hospital

Saint Paul, Minnesota 55102, United States

Saint Francis Regional Medical Center

Shakopee, Minnesota 55379, United States

Lakeview Hospital

Stillwater, Minnesota 55082, United States

Ridgeview Medical Center

Waconia, Minnesota 55387, United States

Rice Memorial Hospital

Willmar, Minnesota 56201, United States

Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota 55125, United States

University of Mississippi Medical Center

Jackson, Mississippi 39216, United States

Saint Francis Medical Center

Cape Girardeau, Missouri 63703, United States

Southeast Cancer Center

Cape Girardeau, Missouri 63703, United States

Siteman Cancer Center - Saint Peters

City of Saint Peters, Missouri 63376, United States

University of Missouri - Ellis Fischel

Columbia, Missouri 65212, United States

Barnes-Jewish West County Hospital

Creve Coeur, Missouri 63141, United States

Mercy Hospital-Joplin

Joplin, Missouri 64804, United States

Truman Medical Center

Kansas City, Missouri 64108, United States

Saint Luke's Hospital of Kansas City

Kansas City, Missouri 64111, United States

Kansas City Veterans Affairs Medical Center

Kansas City, Missouri 64128, United States

The University of Kansas Cancer Center-South

Kansas City, Missouri 64131, United States

Research Medical Center

Kansas City, Missouri 64132, United States

The University of Kansas Cancer Center-North

Kansas City, Missouri 64154, United States

The University of Kansas Cancer Center-Lee's Summit

Lee's Summit, Missouri 64064, United States

Delbert Day Cancer Institute at PCRMC

Rolla, Missouri 65401, United States

Heartland Regional Medical Center

Saint Joseph, Missouri 64506, United States

Mercy Hospital Springfield

Springfield, Missouri 65804, United States

CoxHealth South Hospital

Springfield, Missouri 65807, United States

Saint Louis Cancer and Breast Institute-South City

St Louis, Missouri 63109, United States

Washington University School of Medicine

St Louis, Missouri 63110, United States

Missouri Baptist Medical Center

St Louis, Missouri 63131, United States

Mercy Hospital Saint Louis

St Louis, Missouri 63141, United States

Billings Clinic Cancer Center

Billings, Montana 59101, United States

Saint Vincent Healthcare

Billings, Montana 59101, United States

Montana Cancer Consortium NCORP

Billings, Montana 59102, United States

Bozeman Deaconess Hospital

Bozeman, Montana 59715, United States

Benefis Healthcare- Sletten Cancer Institute

Great Falls, Montana 59405, United States

CHI Health Saint Francis

Grand Island, Nebraska 68803, United States

CHI Health Good Samaritan

Kearney, Nebraska 68847, United States

Nebraska Methodist Hospital

Omaha, Nebraska 68114, United States

Alegent Health Immanuel Medical Center

Omaha, Nebraska 68122, United States

Alegent Health Bergan Mercy Medical Center

Omaha, Nebraska 68124, United States

Alegent Health Lakeside Hospital

Omaha, Nebraska 68130, United States

Creighton University Medical Center

Omaha, Nebraska 68131, United States

Nevada Cancer Research Foundation CCOP

Las Vegas, Nevada 89106, United States

Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada 89148, United States

Comprehensive Cancer Centers of Nevada - Central Valley

Las Vegas, Nevada 89169, United States

Renown Regional Medical Center

Reno, Nevada 89502, United States

New Hampshire Oncology Hematology PA-Concord

Concord, New Hampshire 03301, United States

New Hampshire Oncology Hematology PA-Hooksett

Hooksett, New Hampshire 03106, United States

LRGHealthcare-Lakes Region General Hospital

Laconia, New Hampshire 03246, United States

Veterans Adminstration New Jersey Health Care System

East Orange, New Jersey 07018-1095, United States

Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey 08903, United States

Sparta Cancer Treatment Center

Sparta, New Jersey 07871, United States

Lovelace Medical Center-Downtown

Albuquerque, New Mexico 87102, United States

University of New Mexico Cancer Center

Albuquerque, New Mexico 87102, United States

Hematology Oncology Associates

Albuquerque, New Mexico 87106, United States

Memorial Medical Center - Las Cruces

Las Cruces, New Mexico 88011, United States

Christus Saint Vincent Regional Cancer Center

Santa Fe, New Mexico 87505, United States

Veteran Affairs New York Harbor Healthcare System-Brooklyn Campus

Brooklyn, New York 11209, United States

Veterans Affairs Western New York Health Care System-Buffalo

Buffalo, New York 14215, United States

Roswell Park Cancer Institute

Buffalo, New York 14263, United States

Hematology Oncology Associates of Central New York-East Syracuse

East Syracuse, New York 13057, United States

Arnot Ogden Medical Center/Falck Cancer Center

Elmira, New York 14905, United States

Glens Falls Hospital

Glens Falls, New York 12801, United States

Orange Regional Medical Center

Middletown, New York 10940, United States

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York 10016, United States

Columbia University/Herbert Irving Cancer Center

New York, New York 10032, United States

Weill Medical College of Cornell University

New York, New York 10065, United States

University of Rochester

Rochester, New York 14642, United States

State University of New York Upstate Medical University

Syracuse, New York 13210, United States

Montefiore Medical Center-Weiler Hospital

The Bronx, New York 10461, United States

Montefiore Medical Center - Moses Campus

The Bronx, New York 10467-2490, United States

Dickstein Cancer Treatment Center

White Plains, New York 10601, United States

Mission Hospital-Memorial Campus

Asheville, North Carolina 28801, United States

Carolinas Medical Center/Levine Cancer Institute

Charlotte, North Carolina 28203, United States

Carolinas HealthCare System NorthEast

Concord, North Carolina 28025, United States

Hendersonville Hematology and Oncology at Pardee

Hendersonville, North Carolina 28791, United States

Margaret R Pardee Memorial Hospital

Hendersonville, North Carolina 28791, United States

Park Ridge Hospital Breast Health Center

Hendersonville, North Carolina 28792, United States

Kinston Medical Specialists PA

Kinston, North Carolina 28501, United States

Carolinas HealthCare System Union

Monroe, North Carolina 28112, United States

Carolinas HealthCare System Cleveland

Shelby, North Carolina 28150, United States

Iredell Memorial Hospital

Statesville, North Carolina 28677, United States

Southeast Clinical Oncology Research (SCOR) Consortium NCORP

Winston-Salem, North Carolina 27104, United States

Sanford Bismarck Medical Center

Bismarck, North Dakota 58501, United States

Roger Maris Cancer Center

Fargo, North Dakota 58122, United States

Sanford Clinic North-Fargo

Fargo, North Dakota 58122, United States

Sanford Medical Center-Fargo

Fargo, North Dakota 58122, United States

Summa Akron City Hospital/Cooper Cancer Center

Akron, Ohio 44304, United States

Summa Barberton Hospital

Barberton, Ohio 44203, United States

Adena Regional Medical Center

Chillicothe, Ohio 45601, United States

The Christ Hospital

Cincinnati, Ohio 45219, United States

University of Cincinnati/Barrett Cancer Center

Cincinnati, Ohio 45219, United States

MetroHealth Medical Center

Cleveland, Ohio 44109, United States

Ohio State University Comprehensive Cancer Center

Columbus, Ohio 43210, United States

Columbus Oncology and Hematology Associates Inc

Columbus, Ohio 43214, United States

Riverside Methodist Hospital

Columbus, Ohio 43214, United States

Columbus NCI Community Oncology Research Program

Columbus, Ohio 43215, United States

Grant Medical Center

Columbus, Ohio 43215, United States

The Mark H Zangmeister Center

Columbus, Ohio 43219, United States

Mount Carmel Health Center West

Columbus, Ohio 43222, United States

Good Samaritan Hospital - Dayton

Dayton, Ohio 45406, United States

Miami Valley Hospital

Dayton, Ohio 45409, United States

Samaritan North Health Center

Dayton, Ohio 45415, United States

Dayton NCI Community Oncology Research Program

Dayton, Ohio 45420, United States

Veteran Affairs Medical Center

Dayton, Ohio 45428, United States

Delaware Health Center-Grady Cancer Center

Delaware, Ohio 43015, United States

Armes Family Cancer Center

Findlay, Ohio 45840, United States

Orion Cancer Care

Findlay, Ohio 45840, United States

Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio 45005-1066, United States

Dayton Physicians LLC-Atrium

Franklin, Ohio 45005, United States

Kettering Medical Center

Kettering, Ohio 45429, United States

Saint Rita's Medical Center

Lima, Ohio 45801, United States

Marietta Memorial Hospital

Marietta, Ohio 45750, United States

Toledo Clinic Cancer Centers-Maumee

Maumee, Ohio 43537, United States

Saint Charles Hospital

Oregon, Ohio 43616, United States

Mercy Health Perrysburg Cancer Center

Perrysburg, Ohio 43551, United States

Southern Ohio Medical Center

Portsmouth, Ohio 45662, United States

Springfield Regional Medical Center

Springfield, Ohio 45505, United States

Mercy Saint Anne Hospital

Toledo, Ohio 43623, United States

Toledo Clinic Cancer Centers-Toledo

Toledo, Ohio 43623, United States

Upper Valley Medical Center

Troy, Ohio 45373, United States

Saint Ann's Hospital

Westerville, Ohio 43081, United States

Wright-Patterson Medical Center

Wpafb, Ohio 45433-5529, United States

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma 73104, United States

Oklahoma Cancer Specialists and Research Institute-Tulsa

Tulsa, Oklahoma 74146, United States

Legacy Mount Hood Medical Center

Gresham, Oregon 97030, United States

Legacy Good Samaritan Hospital and Medical Center

Portland, Oregon 97210, United States

Kaiser Permanente Northwest

Portland, Oregon 97227, United States

Oregon Health and Science University

Portland, Oregon 97239, United States

Portland Veterans Administration Medical Center

Portland, Oregon 97239, United States

Legacy Meridian Park Hospital

Tualatin, Oregon 97062, United States

Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania 18103, United States

Lehigh Valley Hospital - Muhlenberg

Bethlehem, Pennsylvania 18017, United States

Doylestown Hospital

Doylestown, Pennsylvania 18901, United States

Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania 17033-0850, United States

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania 19107, United States

Fox Chase Cancer Center

Philadelphia, Pennsylvania 19111, United States

Temple University Hospital

Philadelphia, Pennsylvania 19140, United States

Hematology and Oncology Associates of North East Pennsylvania

Scranton, Pennsylvania 18508, United States

Reading Hospital

West Reading, Pennsylvania 19611, United States

AnMed Health Cancer Center

Anderson, South Carolina 29621, United States

Roper Hospital

Charleston, South Carolina 29401, United States

Charleston Hematology Oncology Associates-Roper

Charleston, South Carolina 29403, United States

Charleston Hematology Oncology Associates PA-St. Francis

Charleston, South Carolina 29414, United States

Medical University of South Carolina

Charleston, South Carolina 29425, United States

Greenville Health System Cancer Institute-Easley

Easley, South Carolina 29640, United States

Saint Francis Hospital

Greenville, South Carolina 29601, United States

Greenville Health System Cancer Institute-Butternut

Greenville, South Carolina 29605, United States

Greenville Health System Cancer Institute-Faris

Greenville, South Carolina 29605, United States

Greenville Memorial Hospital

Greenville, South Carolina 29605, United States

Saint Francis Cancer Center

Greenville, South Carolina 29607, United States

Greenville Health System Cancer Institute-Eastside

Greenville, South Carolina 29615, United States

Self Regional Healthcare

Greenwood, South Carolina 29646, United States

Greenville Health System Cancer Institute-Greer

Greer, South Carolina 29650, United States

Greenville Health System Cancer Institute-Seneca

Seneca, South Carolina 29672, United States

Spartanburg Medical Center

Spartanburg, South Carolina 29303, United States

Greenville Health System Cancer Institute-Spartanburg

Spartanburg, South Carolina 29307, United States

Sanford Cancer Center-Oncology Clinic

Sioux Falls, South Dakota 57104, United States

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota 57117-5134, United States

University of Tennessee - Knoxville

Knoxville, Tennessee 37920, United States

Meharry Medical College

Nashville, Tennessee 37208, United States

Lyndon Baines Johnson General Hospital

Houston, Texas 77026-1967, United States

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas 77030, United States

Ben Taub General Hospital

Houston, Texas 77030, United States

M D Anderson Cancer Center

Houston, Texas 77030, United States

Michael E DeBakey VA Medical Center

Houston, Texas 77030, United States

MD Anderson Regional Care Center-Katy

Houston, Texas 77094, United States

MD Anderson Regional Care Center-Bay Area

Nassau Bay, Texas 77058, United States

MD Anderson Regional Care Center-Sugar Land

Sugar Land, Texas 77478, United States

MD Anderson Regional Care Center-The Woodlands

The Woodlands, Texas 77384, United States

Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah 84112, United States

Inova Fairfax Hospital

Falls Church, Virginia 22042, United States

Lynchburg Hematology-Oncology Clinic

Lynchburg, Virginia 24501, United States

Memorial Hospital Of Martinsville

Martinsville, Virginia 24115, United States

Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia 23298, United States

VCU Community Memorial Health Center

South Hill, Virginia 23970, United States

Shenandoah Oncology Associates PC

Winchester, Virginia 22601, United States

MultiCare Auburn Medical Center

Auburn, Washington 98001, United States

PeaceHealth Saint Joseph Medical Center

Bellingham, Washington 98225, United States

Highline Medical Center-Main Campus

Burien, Washington 98166, United States

Providence Regional Cancer Partnership

Everett, Washington 98201, United States

MultiCare Gig Harbor Medical Park

Gig Harbor, Washington 98335, United States

Kadlec Clinic Hematology and Oncology

Kennewick, Washington 99336, United States

Seattle Cancer Care Alliance at EvergreenHealth

Kirkland, Washington 98034, United States

Skagit Valley Hospital

Mount Vernon, Washington 98274, United States

Jefferson Healthcare

Port Townsend, Washington 98368, United States

MultiCare Good Samaritan Hospital

Puyallup, Washington 98372, United States

Minor and James Medical PLLC

Seattle, Washington 98104, United States

Fred Hutchinson Cancer Research Center

Seattle, Washington 98109, United States

Group Health Cooperative-Seattle

Seattle, Washington 98112, United States

Swedish Medical Center-First Hill

Seattle, Washington 98122-4307, United States

University of Washington Medical Center

Seattle, Washington 98195, United States

Rockwood Cancer Treatment Center-DHEC-Downtown

Spokane, Washington 99204, United States

Rockwood Clinic

Spokane, Washington 99220, United States

Rockwood Clinic Cancer Treatment Center-Valley

Spokane Valley, Washington 99216, United States

MultiCare Tacoma General Hospital

Tacoma, Washington 98405, United States

Northwest NCI Community Oncology Research Program

Tacoma, Washington 98405, United States

Madigan Army Medical Center

Tacoma, Washington 98431, United States

Legacy Salmon Creek Hospital

Vancouver, Washington 98686, United States

Providence Saint Mary Regional Cancer Center

Walla Walla, Washington 99362, United States

West Virginia University Charleston

Charleston, West Virginia 25304, United States

Edwards Comprehensive Cancer Center

Huntington, West Virginia 25701, United States

Langlade Hospital and Cancer Center

Antigo, Wisconsin 54409, United States

Aurora Cancer Care-Southern Lakes VLCC

Burlington, Wisconsin 53105, United States

Marshfield Clinic-Chippewa Center

Chippewa Falls, Wisconsin 54729, United States

Marshfield Clinic Cancer Center at Sacred Heart

Eau Claire, Wisconsin 54701, United States

Sacred Heart Hospital

Eau Claire, Wisconsin 54701, United States

Aurora Health Center-Fond du Lac

Fond du Lac, Wisconsin 54937, United States

Aurora Health Care Germantown Health Center

Germantown, Wisconsin 53022, United States

Aurora Cancer Care-Grafton

Grafton, Wisconsin 53024, United States

Green Bay Oncology at Saint Vincent Hospital

Green Bay, Wisconsin 54301-3526, United States

Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin 54301, United States

Green Bay Oncology Limited at Saint Mary's Hospital

Green Bay, Wisconsin 54303, United States

Saint Vincent Hospital Cancer Center at Saint Mary's

Green Bay, Wisconsin 54303, United States

Aurora BayCare Medical Center

Green Bay, Wisconsin 54311, United States

UW Cancer Center Johnson Creek

Johnson Creek, Wisconsin 53038, United States

Aurora Cancer Care-Kenosha South

Kenosha, Wisconsin 53142, United States

Gundersen Lutheran Medical Center

La Crosse, Wisconsin 54601, United States

Marshfield Clinic - Ladysmith Center

Ladysmith, Wisconsin 54848, United States

University of Wisconsin Hospital and Clinics

Madison, Wisconsin 53792, United States

Holy Family Memorial Hospital

Manitowoc, Wisconsin 54221, United States

Aurora Bay Area Medical Group-Marinette

Marinette, Wisconsin 54143, United States

Vince Lombardi Cancer Clinic-Marinette

Marinette, Wisconsin 54143, United States

Marshfield Clinic

Marshfield, Wisconsin 54449, United States

Saint Joseph's Hospital

Marshfield, Wisconsin 54449, United States

Aurora Cancer Care-Milwaukee

Milwaukee, Wisconsin 53209, United States

Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin 53215, United States

Froedtert and the Medical College of Wisconsin

Milwaukee, Wisconsin 53226, United States

Aurora Sinai Medical Center

Milwaukee, Wisconsin 53233, United States

Marshfield Clinic-Minocqua Center

Minocqua, Wisconsin 54548, United States

Cancer Center of Western Wisconsin

New Richmond, Wisconsin 54017, United States

Green Bay Oncology - Oconto Falls

Oconto Falls, Wisconsin 54154, United States

Vince Lombardi Cancer Clinic - Oshkosh

Oshkosh, Wisconsin 54904, United States

Aurora Cancer Care-Racine

Racine, Wisconsin 53406, United States

Marshfield Clinic at James Beck Cancer Center

Rhinelander, Wisconsin 54501, United States

Saint Mary's Hospital

Rhinelander, Wisconsin 54501, United States

Marshfield Clinic-Rice Lake Center

Rice Lake, Wisconsin 54868, United States

HSHS Saint Nicholas Hospital

Sheboygan, Wisconsin 53081, United States

Vince Lombardi Cancer Clinic-Sheboygan

Sheboygan, Wisconsin 53081, United States

Marshfield Clinic Cancer Care at Saint Michael's Hospital

Stevens Point, Wisconsin 54481, United States

Saint Michael's Hospital

Stevens Point, Wisconsin 54481, United States

Marshfield Clinic Stevens Point Center

Stevens Point, Wisconsin 54482, United States

Saint Vincent Hospital Cancer Center at Sturgeon Bay

Sturgeon Bay, Wisconsin 54235-1495, United States

Green Bay Oncology - Sturgeon Bay

Sturgeon Bay, Wisconsin 54235, United States

Aurora Medical Center in Summit

Summit, Wisconsin 53066, United States

Vince Lombardi Cancer Clinic-Two Rivers

Two Rivers, Wisconsin 54241, United States

Aurora Cancer Care-Waukesha

Waukesha, Wisconsin 53188, United States

Aspirus Regional Cancer Center

Wausau, Wisconsin 54401, United States

Marshfield Clinic-Wausau Center

Wausau, Wisconsin 54401, United States

Aurora Cancer Care-Milwaukee West

Wauwatosa, Wisconsin 53226, United States

Aurora West Allis Medical Center

West Allis, Wisconsin 53227, United States

Diagnostic and Treatment Center

Weston, Wisconsin 54476, United States

Marshfield Clinic - Weston Center

Weston, Wisconsin 54476, United States

Aspirus UW Cancer Center

Wisconsin Rapids, Wisconsin 54494, United States

Marshfield Clinic - Wisconsin Rapids Center

Wisconsin Rapids, Wisconsin 54494, United States

Billings Clinic-Cody

Cody, Wyoming 82414, United States