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A) Background Chronic neck pain is a significant and common issue which is difficult to treat. Tight bands of muscle (trigger points) can be a source of chronic neck pain and they are sometimes injected to manage chronic neck pain. However, these injections seldom lead to significant, long-lasting relief. In some cases, these trigger points may originate from injury or damage to a specific joint in the neck (the facet joint). Treatment of this joint with cortisone injection may lead to improved pain relief and function.
B) Hypothesis By injecting the facet joint with cortisone, the pain associated with tight bands of muscle in the neck and shoulders will be relieved to a greater extent than that attained through trigger point injection.
C) Methods Patients with neck pain will have a test to determine if any pain originates from the facet joint. Among those who have significant pain from these joints, a comparison between the effect of cortisone injection into these joints versus injection into the trigger points will be evaluated.
D) Expected Results and Significance
It is expected that injection with cortisone into the facet joints will lead to improved pain and function when compared to that attained from trigger point injection. In addition, the number of trigger points, and the pain and headache that originate from these trigger points, are expected to decrease with cortisone injection into the facets to a statistically and clinically significant extent. Results from this pilot study will then influence the design of future trials into chronic neck pain treatment, leading to better clinical recommendations. A peer-reviewed publication and conference presentations will facilitate dissemination.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dexamethasone | Experimental | Intra-articular corticosteroid number 2. |
|
| Betamethasone | Experimental | Subjects will receive either betamethasone or dexamethasone injected into the cervical facet joints (levels determined by experienced physician). |
|
| Intramuscular injection | Active Comparator | Subjects in this group will receive lidocaine injection directly into tender myofascial trigger points. |
|
| Home exercise | Active Comparator | Subjects in this group will receive education and a pamphlet on a set of standardized home exercises for neck pain |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Betamethasone | Procedure | 6 mg/mL injected into the facet joint as dictated by modified dual-comparative medial branch block diagnostic protocol |
|
| Measure | Description | Time Frame |
|---|---|---|
| Patient Global Impression of Change (PGIC) | A 15-point self-report scale ranging from 0 = A very great deal worse to 15 = A very great deal better (8 = no change). | 1, 3, and 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Pain Intensity Numeric Rating Scale | 1, 3, and 6 months | |
| Neck Disability Index | 1, 3, and 6 months | |
| Headache Impact Test - 6 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| David M Walton, BScPT, PhD | Western University, Canada | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| St. Joseph's Hospital / Parkwood Hospital | London | Ontario | N6A 4V2 | Canada |
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| ID | Term |
|---|---|
| D019547 | Neck Pain |
| D059350 | Chronic Pain |
| ID | Term |
|---|---|
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D001623 | Betamethasone |
| D003907 | Dexamethasone |
| ID | Term |
|---|---|
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
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| Dexamethasone | Procedure | 4mg/mL |
|
| Intramuscular Lidocaine | Procedure | 2% |
|
| Home Exercise | Behavioral | Standardized home exercise program |
|
| 1, 3, and 6 months |
| Patient Health Questionnaire - 9 | 1, 3, and 6 months |
| Adverse Events Checklist | Constructed specifically for this study. | 1, 3, and 6 months |
| Global Cervical Active Range of Motion | Measured using a digital inclinometer | 1, 3, and 6 months |
| Mechanical (Pressure) Pain Threshold | Measured using a digital algometer over standardized myofascial trigger points. | 1, 3, and 6 months |
| D000072473 |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |