Evaluate the use of the autologous ASC for the treatment of bilateral limbic associated keratopathy

Intralesional use by inject of adipose derived stem cells

Inclusion Criteria:

1. -Signed informed consent

2. -Previously diagnosed bilateral limbic obstruction

3. -Men and women over 18 years old. Good general state of health according to the findings of the clinical history and the physical examination

4. -Suffering chronic keratopathy accomplishing the following criteria:

   • Confirmed limbic obstruction with an impression cytology
   • Repeated usual treatment failure for this pathology

Exclusion Criteria:

1. -Having suffered a neoplasia in the previous 5 years
2. -Local anesthesia allergies
3. -Patients having participate in any other study in the previous 90 days to the inclusion
4. -Patients on medication with tacrolimus or cyclosporine in the 4 previous week to the cellular therapy
5. -Any medical or psychiatric illness that, in the investigator opinion, could suppose a reason for the study exclusion
6. -Patients with any type of medical or psychiatric disease which, in the opinion of the investigator, could be grounds for exclusion from study
7. -Patients with congenital or acquired immunodeficiencies. HIV, HBV, HCV or treponema infection, whether active or latent
8. -Patients who have suffering major surgery or severe trauma in the prior 6 months
9. -Pregnant or breastfeeding women