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The purpose of this study is to determine if multiple vaccination in military personnel may be correlated with the appearance of poorly defined diseases as symptomatic multisyndrome, autoimmune or lymphoproliferative disorders. At the same time, considering possible interference between different vaccines, proteins and polysaccharides, living and inactivated, the study aims to assess the immunogenicity and efficacy also in relation to the specific Human Leucocyte Antigens (HLA) genetic structure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| single arm :vaccinated | Other | military personnel vaccinated with multiple vaccines and monitored about safety, immunogenicity and efficacy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| biological monitoring | Biological |
|
| Measure | Description | Time Frame |
|---|---|---|
| immunomediated disorders related to multiple vaccination | three years |
| Measure | Description | Time Frame |
|---|---|---|
| efficacy of multiple vaccination | Three years | |
| immunogenicity of multiple vaccination | Three years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Raffaele D'Amelio, MD | sapienza università di roma | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Roma La Sapienza | Roma | Italia | 00185 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30269918 | Derived | Ferlito C, Biselli R, Mariotti S, von Hunolstein C, Teloni R, Ralli L, Pinto A, Pisani G, Tirelli V, Biondo MI, Salerno G, Andreasi Bassi L, Lulli P, Autore A, Scagliusi A, Tomao E, Germano V, Picchianti Diamanti A, Caporuscio S, Milanetti F, Salemi S, Nisini R, D'Amelio R. Tetanus-diphtheria vaccination in adults: the long-term persistence of antibodies is not dependent on polyclonal B-cell activation and the defective response to diphtheria toxoid re-vaccination is associated to HLADRB1 *01. Vaccine. 2018 Oct 29;36(45):6718-6725. doi: 10.1016/j.vaccine.2018.09.041. Epub 2018 Sep 27. |
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| ID | Term |
|---|---|
| D000079687 | Biological Monitoring |
| ID | Term |
|---|---|
| D004784 | Environmental Monitoring |
| D004781 | Environmental Exposure |
| D004787 | Environmental Pollution |
| D011634 | Public Health |
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| D004778 |
| Environment and Public Health |
| D015980 | Public Health Practice |