Observational - Tissue Factor Expression in Bone Sarcomas
Observational - Tissue Factor Expression in Bone Sarcomas
This trial studies biomarker expression in tissue samples from patients with bone sarcomas. Studying biomarker in tissue samples from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer
STUDY SUBTYPE: Ancillary/Correlative
OBSERVATIONAL STUDY MODEL: Case-only
TIME PERSPECTIVE: Retrospective
BIOSPECIMEN RETENTION: Samples without DNA
BIOSPECIMEN DESCRIPTION: Tissue samples obtained from Cooperative Human Tissue Network (CHTN)
STUDY POPULATION DESCRIPTION: Patients enrolled on P9754 and AOST0121 clinical trials
SAMPLING METHOD: Non-probability sample
PRIMARY OBJECTIVES:
I. To determine if there is differential expression of tumor factor (TF) among patients with osteosarcoma.
II. To determine if there is an association between overall survival and disease free survival and the extent of TF expression.
III. To determine if TF expression correlates with presence of gross metastatic disease at presentation, and development of subsequent metastases.
OUTLINE:
Tissue samples are analyzed for tumor factor expression levels by immunohistochemistry.
Inclusion Criteria:
Tissue samples from patients with osteosarcomas obtained from the CHTN: