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Clinical trial to evaluate the pharmacokinetic interactions and safety between telmisartan and chlorthalidone.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Part A: Telmisartan, Chlorthalidone + Telmisartan | Active Comparator | telmisartan 80mg : multiple dose administered orally chlorthalidone 25mg : multiple dose administered orally |
|
| Part B: Chlorthalidone, Chlorthalidone + Telmisartan | Active Comparator | telmisartan 80mg : multiple dose administered orally chlorthalidone 25mg : multiple dose administered orally |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Telmisartan 80mg | Drug |
| ||
| Measure | Description | Time Frame |
|---|---|---|
| Part A : AUC, Cmax of Telmisartan | Over a 24-hour sampling period | |
| Part B : AUC, Cmax of Chlorthalidone | Over a 24-hour sampling period |
| Measure | Description | Time Frame |
|---|---|---|
| Part A : Cmin, tmax, CL/F of Telmisartan | Over a 24-hour sampling period | |
| Part B : Cmin, tmax, CL/F of Chlorthalidone | Over a 24-hour sampling period |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Young Ran Yoon, Associate Professor | KYUNGPOOK NATIONAL UNIVERSITY HOSPITAL, CLINICAL TRIAL CENTER | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kyungpook national university hospital Clionical center | Daegu | Gyeongsangbuk-do | 700-721 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27206575 | Derived | Seong SJ, Lim MS, Lee J, Ohk B, Gwon MR, Kim BK, Kim HJ, Yang DH, Lee HW, Kang WY, Yoon YR. Evaluation of a Pharmacokinetic Interaction between Telmisartan and Chlorthalidone in Healthy Male Adult Subjects. Clin Drug Investig. 2016 Aug;36(8):613-23. doi: 10.1007/s40261-016-0406-y. |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D000077333 | Telmisartan |
| D002752 | Chlorthalidone |
| ID | Term |
|---|---|
| D001713 | Biphenyl Compounds |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
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| Chlorthalidone 25mg |
| Drug |
|
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |
| D001562 | Benzimidazoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D000096926 | Benzenesulfonamides |
| D013449 | Sulfonamides |
| D000577 | Amides |
| D001577 | Benzophenones |
| D010797 | Phthalimides |
| D007094 | Imides |
| D007659 | Ketones |
| D013450 | Sulfones |
| D013457 | Sulfur Compounds |
| D054833 | Isoindoles |