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The aim of this study is to assess the influence of kind of allergic disease, allergic profile, allergen exposure, treatment method on lung function parameters, fractional exhaled nitric oxide level in children suspected and being diagnosed due to allergic diseases.
The aim of this study is to assess the influence of kind of allergic disease, allergic profile, allergen exposure, treatment method on lung function parameters, fractional exhaled nitric oxide (FeNO) level in children suspected and being diagnosed due to allergic diseases.
Study will be retrospective, conducted in all children diagnosed in the years of 2005-20012 in Laboratory of lung function tests of Department of Pediatrics and Allergy, Medical University of Lodz, N. Copernicus Hospital, Lodz, Poland. The investigators will analyse 5500 male an female children 5-18 year old suspected and being diagnosed due to allergic diseases. In these children nearly 3000 FeNO measurements, 65000 spirometry measurements, 22000 whole-body plethysmography measurements and 48000 occlusion resistance measurements were performed between the years of 2005-2012.
The investigators will retrospectively evaluate following data from medical documentation of patients:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Children suspected of allergic diseases | Children suspected of allergic diseases No intervention |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention | Other | No intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| Allergic disease diagnosis | Allergic disease diagnosis. The diagnosis and the severity of asthma, allergic rhinitis and atopic dermatitis and other allergic diseases universally established by the doctors (allergologists) according to standard definitions of diseases in the latest guidelines | 7 years |
| Measure | Description | Time Frame |
|---|---|---|
| Lung function (LF) | spirometry, whole-body pletysmography, occlusion resistance, bronchial reversibility test | 7 years |
| Measure | Description | Time Frame |
|---|---|---|
| Fractional exhaled nitric oxide (FeNO) | Fractional exhaled nitric oxide (Sievers equipment) | 7 years |
| Immunoglobulin E (IgE) allergen specific | Immunoglobulin E (IgE) allergen specific (ELISA method) |
Inclusion Criteria:
Exclusion Criteria:
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Children with allergic diseases, healthy children.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Iwona Stelmach, MDPhDProf | Contact | 48426895972 | alergol@kopernik.lodz.pl | |
| Tomasz Grzelewski, MD PhD | Contact | 48426895972 | alergol@kopernik.lodz.pl |
| Name | Affiliation | Role |
|---|---|---|
| Iwona Stelmach, MDPhDProf | Department of Pediatrics and Allergy, Medical University of Lodz, N. Copernicus Hospital, Lodz, Poland | Study Chair |
| Tomasz Grzelewski, MDPhD | Department of Pediatrics and Allergy, Medical University of Lodz, N. Copernicus Hospital, Lodz, Poland |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Pediatrics and Allergy, Medical University of Lodz, N. Copernicus Hospital | Recruiting | Lodz | 93-513 | Poland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26628565 | Derived | Grzelewski T, Stelmach W, Stelmach R, Janas A, Grzelewska A, Witkowski K, Makandjou-Ola E, Majak P, Stelmach I. Spirometry-Adjusted Fraction of Exhaled Nitric Oxide Allows Asthma Diagnosis in Children, Adolescents, and Young Adults. Respir Care. 2016 Feb;61(2):162-72. doi: 10.4187/respcare.04092. Epub 2015 Dec 1. | |
| 26216360 | Derived |
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| ID | Term |
|---|---|
| D001249 | Asthma |
| D065631 | Rhinitis, Allergic |
| D003876 | Dermatitis, Atopic |
| D014581 | Urticaria |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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IgE specific allergen antibodies
| 7 years |
| Treatment of asthma (drugs and dosages) | Treatment of asthma (drugs and dosages last 3 months before measurement of lung function parameters and FeNO) | 7 years |
| Principal Investigator |
| Jerzynska J, Janas A, Galica K, Stelmach W, Woicka-Kolejwa K, Stelmach I. Total specific airway resistance vs spirometry in asthma evaluation in children in a large real-life population. Ann Allergy Asthma Immunol. 2015 Oct;115(4):272-6. doi: 10.1016/j.anai.2015.07.002. Epub 2015 Jul 26. |
| 24019244 | Derived | Grzelewski T, Witkowski K, Makandjou-Ola E, Grzelewska A, Majak P, Jerzynska J, Janas A, Stelmach R, Stelmach W, Stelmach I. Diagnostic value of lung function parameters and FeNO for asthma in schoolchildren in large, real-life population. Pediatr Pulmonol. 2014 Jul;49(7):632-40. doi: 10.1002/ppul.22888. Epub 2013 Sep 9. |
| D012130 |
| Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D012220 | Rhinitis |
| D009668 | Nose Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D012873 | Skin Diseases, Genetic |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D003872 | Dermatitis |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D017443 | Skin Diseases, Eczematous |
| D017445 | Skin Diseases, Vascular |