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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CON | Sham Comparator | Patients undergoing double valve replacement (aortic and mitral). |
|
| IPO | Experimental | Patients undergoing double valve replacement (aortic and mitral) with ischemic postconditioning. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ischemic postconditioning | Procedure | multiple brief ischemic-reperfusion episodes immediately after sustained ischemic insult Postconditioning was started at 30 s after aortic cross declamping, and the aorta was re-clamped for 30 s rendering global myocardial ischemia. Meanwhile aortic root suction was established during aortic re-clamping, and thereafter, the aortic clamp was released for 30 s for full myocardial reperfusion. The cycle was repeated three times after cardioplegic arrest. |
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline in Cardiac MicroRNA Expression | Samples were harvested from all the patients, respectively, before cardiopulmonary bypass and at 5 min after aortic de-clamping. Real-time quantitative stem-loop reverse transcription polymerase chain reaction assay was performed to detect the expression of microRNAs. | before cardiopulmonary bypass and at 5 min after aortic de-clamping |
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline in Downstream Gene Expression | Expressions of messenger RNAs and proteins were quantified for genes which are regulated by above-detected microRNAs. | before cardiopulmonary bypass and at 5 min after aortic de-clamping |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Wanjun Luo, MD | Xiangya Hospital of Central South University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xiangya Hospital | Changsha | Hunan | 410008 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26253453 | Derived | Gao Y, Huang R, Chen R, Li J, Luo W. Ischemic postconditioning altered microRNAs in human valve replacement. J Surg Res. 2016 Jan;200(1):28-35. doi: 10.1016/j.jss.2015.07.010. Epub 2015 Jul 10. |
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| ID | Term |
|---|---|
| D057775 | Ischemic Postconditioning |
| D006355 | Heart-Lung Machine |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
| D001187 | Artificial Organs |
| D013523 | Surgical Equipment |
| D004864 | Equipment and Supplies |
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|
| double valve replacement | Procedure | The double valve replacement is a procedure in which surgery is used to replace diseased aortic and mitral heart valves. |
|
| heart-lung machine | Device | The heart-lung machine is commonly used in open heart surgery including double valve replacement to support the circulation during the operation. |
|
| Aortic cross-clamp | Device | a surgical instrument used in cardiac surgery to clamp the aorta |
|