Effects of Ischemic Postconditioning on MicroRNAs in Double Valve Replacement

Effects of Ischemic Postconditioning on Expression of Apoptosis-related MicroRNAs and Genes in Human Double Valve Replacement

1. Cardiopulmonary bypass and cardioplegic arrest could regulate expression of microRNAs in patients undergoing double valve replacement (aortic and mitral).
2. The modulation of myocardial microRNAs by cardiopulmonary bypass and cardioplegic arrest may be rescued by ischemic postconditioning.
3. Downstream effectors would also be affected.

Inclusion Criteria:

• Consecutive eight patients with rheumatic heart valve disease undergoing elective double valve replacement(aortic and mitral)are considered for participation in this study.

Exclusion Criteria:

• insulin-dependent diabetes mellitus
• pulmonary, renal, or hepatic failure
• infective valve disease
• valve disease with coronary artery disease
• hypertension
• emergency and reoperations
• received aspirin,corticosteroids, or statin preoperatively
• received preoperative inotropic support