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Cardiac dysfunction can occur in aneurysmal subarachnoid haemorrhage and might impact patient's neurologic outcome Condition Aneurysmal subarachnoid haemorrhage World Neurosurgeon Federation Score ≥ III
Trans-thoracic echocardiography on day 1, day 3 and day 7 Speckle-Tracking of echocardiographic loops by a cardiologist blinded to the patient's management and outcome
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Aneurysmal subarachnoid haemorrhage | Speckle-tracking images in Echocardiography |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Echocardiography | Procedure | Speckle-Tracking of echocardiographic loops by a cardiologist blinded to the patient's management and outcome |
|
| Measure | Description | Time Frame |
|---|---|---|
| Neurologic outcome | modified Rankin Scale (mRS). Poor neurological outcome was considered as death or severe disability (mRS 5-6). | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between cardiac strain on day 1 and Left Ventricular Ejection fraction | Day 1 | |
| Correlation between cardiac enzymes (NT-proBNP, troponin T US) and cardiac strain | Day 1 | |
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Inclusion Criteria:
Exclusion Criteria:
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Severe Aneurysmal subarachnoid haemorrhage
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| Name | Affiliation | Role |
|---|---|---|
| Raphael Cinotti, MD | Nantes University Hospital | Principal Investigator |
| Bertrand ROZEC, PhD, MD | Nantes University Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital | Nantes | 44000 | France | |||
| University Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19269254 | Background | Hofmeijer J, Kappelle LJ, Algra A, Amelink GJ, van Gijn J, van der Worp HB; HAMLET investigators. Surgical decompression for space-occupying cerebral infarction (the Hemicraniectomy After Middle Cerebral Artery infarction with Life-threatening Edema Trial [HAMLET]): a multicentre, open, randomised trial. Lancet Neurol. 2009 Apr;8(4):326-33. doi: 10.1016/S1474-4422(09)70047-X. Epub 2009 Mar 5. |
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| Correlation between EKG findings and cardiac strain |
| Day 1 |
| Time to amines discontinuation | During Intensive Care Unit stay, expected average 17 days |
| Duration of mechanical ventilation | Duration of mechanical ventilation, expected average 15 days |
| Length of ICU stay | Duration of ICU stay, expected average 17 days |
| Correlation between Cardiac function and Mechanical Ventilation | Day1, day3, day7 and extubation time expected average 15 days |
| Correlation between Cardiac function and ICU length of stay | Day1, day3, day 7 and end of stay in ICU expected average 17 days |
| Rennes |
| 35000 |
| France |