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The current study investigates the basic principles that underlie the efficacy of transcranial direct current stimulation for chronic auditory verbal hallucinations in schizophrenia in a multimodal design.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| verum tDCS | Experimental | left-hemispheric tDCS: anode placed midway between F3 and FP1, cathode placed midway between T3 and P3 |
|
| sham tDCS | Sham Comparator | left-hemispheric sham tDCS: anode placed midway between F3 and FP1, cathode placed midway between T3 and P3 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tDCS | Device | active vs. sham tDCS left hemisphere |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of Auditory Hallucination Rating Scale score | Auditory Hallucination Rating Scale score will be assessed at baseline; changes thereof at 3 days after intervention and 3 months after intervention are primary outcome measures | baseline; 3 days after intervention; 3 months after intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Positive And Negative Syndrome Scale | Positive And Negative Syndrome Scale score will be assessed at baseline; changes thereof at 3 days after intervention and 3 months after intervention are secondary outcome measures | baseline; 3 days after intervention; 3 months after intervention |
| Measure | Description | Time Frame |
|---|---|---|
| N1 suppression during talking and listening | N1 suppression during talking and listening will be assessed at baseline; change thereof at 3 days after intervention is further outcome measure | baseline; 3 days after intervention |
| Diffusion Tensor Imaging: Fractional anisotropy of longitudinal superior fascicle and arcuate fascicle |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Robert Lindenberg, MD | Department of Neurology, Charité University Medicine Berlin | Principal Investigator |
| Andres H. Neuhaus, MD | Department of Psychiatry, Charité University Medicine Berlin | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charité University Medicine | Berlin | 10117 | Germany | |||
| Charité University Medicine |
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| ID | Term |
|---|---|
| D006212 | Hallucinations |
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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Fractional anisotropy of longitudinal superior fascicle and arcuate fascicle will be assessed at baseline; change thereof 3 days after intervention is further outcome measure |
| baseline; 3 days after intervention |
| Default Mode Network connectivity | Default Mode Network connectivity will be assessed at baseline; change thereof 3 days after intervention is further outcome measure | baseline; 3 days after intervention |
| Berlin |
| 12203 |
| Germany |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |