Glucose Control in the ICU Using Continuous Glucose Monitoring

Randomized Evaluation of Glycaemic Control in the Medical Intensive Care Unit Using Continuous Glucose Monitoring (REGIMEN Trial)

Stress hyperglycemia occurs in 50-85% of patients admitted to a medical intensive care unit (MICU) and is associated with increased morbidity and mortality. However, randomized controlled trials examining the effects of strict glycemic control demonstrated conflicting results. A common finding in these trials was the high risk of hypoglycaemia.

This randomized controlled trial evaluates the impact of real-time continuous glucose monitoring (RT-CGM) on glycemic control and risk of hypoglycemia in severely ill MICU patients with an APACHE-II (Acute Physiology and Chronic Health Evaluation II) score ≥20.

Inclusion Criteria:

• Patients admitted to a medical intensive care unit
• age: ≥ 18 y , < 75 y
• APACHE II (Acute Physiology and Chronic Health Evaluation II) score ≥ 20
• expected length of stay in ICU > 3 days

Exclusion Criteria:

• pregnancy
• patient with a DNR (do not reanimate) code
• surgical patient
• no informed consent