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| ID | Type | Description | Link |
|---|---|---|---|
| 11YZ65 | Other Grant/Funding Number | Shanghai Municipal Education Commission |
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The purpose of this study is to analysis the different genotype in the idiopathic membranous nephropathy patients which with different therapeutic outcomes after treated by the Comprehensive Treatment Regimen or immunosuppressive agents, and so as to looking for ideal markers to assess appropriate treatment approach and the long-term efficacy.
The primary objective of this study is to looking for the gene level predictors in the patients who suffered from idiopathic membranous nephropathy. And according to the predictors, the clinicians could make a decision which method should be taken on IMN patients, Traditional Chinese Medicine or western medicine, and could get better results.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CR/CTR group | The complete remission group treated by the Comprehensive Treatment Regimen |
| |
| NR/CTR group | The non-remission group treated by the Comprehensive Treatment Regimen |
| |
| CR/IA group | The complete remission group treated by Immunosuppressive Agents |
| |
| NR/IA group | The non-remission group treated by Immunosuppressive Agents. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| The Comprehensive Treatment Regimen of Traditional Chinese Medicine | Drug | ①ShenQiMoShen Decoction: which plays vital therapeutic effect in the CTR,the dosage is 150ml per serving and two services per day.Dosage and administration:150ml per time,twice per day ②HuoXueTongMai Capsule : which plays a vital role of promoting blood circulation and removing blood stasis. Its main components are the leeches. Dosage and administration: 4 capsules 3 times daily. ③HeiLiaoDou Particle: which will be prescribed when hypoproteinemia (serum albumin concentration≤30g/L)occurred and should be stopped taking until the serum albumin is above 30g/L. Dosage and administration: 2 packages 3 times daily. |
| Measure | Description | Time Frame |
|---|---|---|
| Genome-wide single-nucleotide-polymorphism of IMN patients treated by the Comprehensive Treatment Regimen or conventional approach | Screening for single-nucleotide-polymorphism as the prognostic factor for the TCM intervention of IMN patients. | one year |
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Inclusion Criteria:
Exclusion Criteria:
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idiopathic membranous nephropathy
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wang Lin, PHD | Contact | 86-13816583673 | happytlynn@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Wang Lin, PHD,MD | Shanghai University of Traditional Chinese Medicine | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai University of Traditional Chinese Medicine | Recruiting | Shanghai | Shanghai Municipality | 200032 | China |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Jan 13, 2016 | |
| Reset | Feb 10, 2016 | |
| Release | Apr 30, 2023 | |
| Reset | Jan 19, 2024 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jan 13, 2016 | Feb 10, 2016 | |||
| Apr 30, 2023 |
| ID | Term |
|---|---|
| D015433 | Glomerulonephritis, Membranous |
| ID | Term |
|---|---|
| D005921 | Glomerulonephritis |
| D009393 | Nephritis |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
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| ID | Term |
|---|---|
| D005938 | Glucocorticoids |
| D016572 | Cyclosporine |
| D003520 | Cyclophosphamide |
| D016559 | Tacrolimus |
| ID | Term |
|---|---|
| D000305 | Adrenal Cortex Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D045505 | Physiological Effects of Drugs |
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whole blood
|
|
| The immunosuppressive agents | Drug | According to Kidney Disease Improving Global Outcomes (KDIGO) clinical practice guideline for glomerulonephritis |
|
|
| Jan 19, 2024 |
| D052776 |
| Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D003524 | Cyclosporins |
| D010456 | Peptides, Cyclic |
| D047028 | Macrocyclic Compounds |
| D011083 | Polycyclic Compounds |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D010752 | Phosphoramide Mustards |
| D009588 | Nitrogen Mustard Compounds |
| D009150 | Mustard Compounds |
| D006846 | Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D063088 | Phosphoramides |
| D009943 | Organophosphorus Compounds |
| D018942 | Macrolides |
| D007783 | Lactones |