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| Name | Class |
|---|---|
| Center for Neuroscience and Regenerative Medicine (CNRM) | FED |
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The goal of this project is to develop a test to assess frontal lobe function using a rapid, inexpensive, objective, and standardized method, without the need for expertise in cognitive test administration. Such methods would be particularly helpful in traumatic brain injury (TBI), where objective measures are needed, and would greatly expand the capacity to make such assessments in clinical practice and research.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| History of having sustained TBI | Males and females between 18 and 60 years who have a diagnosis of TBI | ||
| Control group | Control group with no history of TBI or concussion. Gender and age matched non-TBI volunteers |
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| Measure | Description | Time Frame |
|---|---|---|
| Measure of hemodynamic response function | In two population groups: TBI and non TBI, we will determine normative data for the cognitive parametric experiment by measuring the local hemodynamic response function with functional near infrared spectroscopy | Two years |
| Measure | Description | Time Frame |
|---|---|---|
| Measure of the degree of impairment | Determine the relationship between hemodynamic response as measured by fNIRS and measures of neuropsychological and behavioral functioning obtained using measures from the NINDS Common Data Elements. | Two years |
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Inclusion Criteria:
Able to read, write, speak and understand English
history of having sustained a TBI prior to enrollment. Evidence will be any one of the following 3 criteria:
Exclusion Criteria:
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Males and females (military health care beneficiaries and non military health care beneficiaries) age between 18 and 60 years who have a diagnosis of moderate or severe traumatic brain injury as well as age, gender, education matched non-TBI volunteers.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center for Neuroscience and Regenerative Medicine (CNRM) | Rockville | Maryland | 20851 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26996413 | Result | Chernomordik V, Amyot F, Kenney K, Wassermann E, Diaz-Arrastia R, Gandjbakhche A. Abnormality of low frequency cerebral hemodynamics oscillations in TBI population. Brain Res. 2016 May 15;1639:194-9. doi: 10.1016/j.brainres.2016.02.018. Epub 2016 Mar 17. |
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| ID | Term |
|---|---|
| D000070642 | Brain Injuries, Traumatic |
| ID | Term |
|---|---|
| D001930 | Brain Injuries |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| D006259 |
| Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |