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In this randomised controlled cross-over study we will investigate whether intrathoracic pressure changes induced by simulated obstructive apnoea and hypopnoea trigger premature supraventricular and ventricular contractions as well as atrial fibrillation in patients with paroxysmal atrial fibrillation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mueller manoeuvre | Active Comparator | Mueller manoeuvre lasting for 20 seconds |
|
| Inspiratory threshold | Active Comparator | One continuous inspiration through an inspiratory threshold load for 20 seconds |
|
| Expiratory apnoea | Active Comparator | Expiratory apnoea (without respiratory effort) lasting for 20 seconds |
|
| Steady state normal breathing | Sham Comparator | Steady state normal breathing for 20 seconds |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mueller manoeuvre | Other |
| ||
| Inspiratory threshold |
| Measure | Description | Time Frame |
|---|---|---|
| Number of subjects with premature myocardial contractions and/or atrial fibrillation | 20 seconds |
| Measure | Description | Time Frame |
|---|---|---|
| ECG-derived myocardial de- and repolarization times | 20 seconds |
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Inclusion criteria:
Exclusion criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Malcolm Kohler, Prof MD | University Hospital Zurich, Division of Pneumology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Zurich, Division of Pneumology | Zurich | Canton of Zurich | 8091 | Switzerland |
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|
| Expiratory apnoea | Other |
|
| Steady state normal breathing | Other |
|