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This is an equivalence study comparing an electric nebulizer with a human-powered nebulizer--one that does not need electricity--in the treatment of mild to moderate asthma exacerbations in a regional clinic in San Salvador, El Salvador.
The study design is to treat individuals suffering from mild to moderate exacerbations of asthma with nebulized salbutamol (2.5mg). Subjects will receive nebulization using either an electric nebulizer compressor or a human-powered nebulizer compressor. Improvement in peak expiratory flow will be the primary endpoint. Blood oxygenation levels as measured by pulse oximetry will be a secondary endpoint of the trial.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Electric Nebulizer | Active Comparator | Pulmo-Aide Model 5650D |
|
| Human-Powered Nebulizer | Experimental | Human-Powered |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Human-Powered Nebulizer | Device |
|
| Measure | Description | Time Frame |
|---|---|---|
| Improvement in Peak Expiratory Flow | From before to after nebulizer treatment lasting approximately 30 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Improvement in blood oxygenation as measured by pulse oximetry | From before to after nebulizer treatment lasting about 30 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Lars E Olson, Ph.D. | Marquette University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Nacional San Bartolo | Ilopango | San Salvador Department | El Salvador |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24965834 | Derived | Hallberg CJ, Lysaught MT, Najarro RA, Cea Gil F, Villatoro C, Diaz de Uriarte AC, Olson LE. Treatment of asthma exacerbations with the human-powered nebuliser: a randomised parallel-group clinical trial. NPJ Prim Care Respir Med. 2014 Jun 26;24:14016. doi: 10.1038/npjpcrm.2014.16. |
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| ID | Term |
|---|---|
| D001249 | Asthma |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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| D012130 |
| Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |