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The study will aim to describe and evaluate the effect of beetroot juice supplementation upon whole body running exercise at altitude. It is hypothesised that beetroot supplementation will decrease time to complete a 10 km time trial.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Beetroot shot then placebo shot | Experimental | Intervention: Participants will first consume a Beetroot shot: 1x70ml concentrated NO-3 shot of rich Beetroot juice (~7mmol nitrate) (Beet It, James White Drinks Ltd, Ipswich, UK). Following a four day wash out, participants will then consume a Nitrate-depleted beetroot shot: 1x70ml nitrate-depleted beetroot Placebo shot (~0.003mmol of nitrate)(Beet It, James White Drinks Ltd, Ipswich, UK) |
|
| Placebo shot then beetroot shot | Placebo Comparator | Intervention: Participants will first consume a Nitrate-depleted beetroot shot: 1x70ml nitrate-depleted beetroot Placebo shot (~0.003mmol of nitrate)(Beet It, James White Drinks Ltd, Ipswich, UK). Following a four day wash out, participants will then consume a Beetroot shot: 1x70ml concentrated NO-3 shot of rich Beetroot juice (~7mmol nitrate) (Beet It, James White Drinks Ltd, Ipswich, UK). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Beetroot shot then placebo shot | Dietary Supplement | Beetroot shot, four day wash out, then placebo shot |
|
| Measure | Description | Time Frame |
|---|---|---|
| Time to Complete a 10 km Run | Time taken following consumption of beetroot shot or consumption of placebo shot | Period 1 (on day of 1st intervention) and period 2 (on day of 2nd intervention) |
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Inclusion Criteria:
- Trained athletes with personal best performances for a 10km run of sub 40 minutes
Exclusion Criteria:
- Unable to give informed consent Unstable medical condition.
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| Name | Affiliation | Role |
|---|---|---|
| Jamie H Macdonald, PhD | Bangor University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bangor University | Bangor | Gwynedd | LL57 2PZ | United Kingdom |
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| ID | Title | Description |
|---|---|---|
| FG000 | Beetroot Shot Then Placebo Shot | Intervention: Participants will first consume a Beetroot shot: 1x70ml concentrated NO-3 shot of rich Beetroot juice (~7mmol nitrate) (Beet It, James White Drinks Ltd, Ipswich, UK). Following a four day wash out, participants will then consume a Nitrate-depleted beetroot shot: 1x70ml nitrate-depleted beetroot Placebo shot (~0.003mmol of nitrate)(Beet It, James White Drinks Ltd, Ipswich, UK) |
| FG001 | Placebo Shot Then Beetroot Shot | Intervention: participants will first consume a Nitrate-depleted beetroot shot: 1x70ml nitrate-depleted beetroot Placebo shot (~0.003mmol of nitrate)(Beet It, James White Drinks Ltd, Ipswich, UK) Following a four day wash out, participants will then consume a Beetroot shot: 1x70ml concentrated NO-3 shot of rich Beetroot juice (~7mmol nitrate) (Beet It, James White Drinks Ltd, Ipswich, UK). |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| First Intervention (First Shot) |
| |||||||||||||
| Wash Out Period (4 Days) |
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| Second Intervention (Second Shot) |
|
Includes groups randomized to receive beetroot shot first and placebo first.
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| ID | Title | Description |
|---|---|---|
| BG000 | All Participants | Includes groups randomized to receive beetroot shot first and placebo first. |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Time to Complete a 10 km Run | Time taken following consumption of beetroot shot or consumption of placebo shot | Posted | Mean | Standard Deviation | Seconds | Period 1 (on day of 1st intervention) and period 2 (on day of 2nd intervention) |
|
During three study periods only (1st intervention, wash out period, second intervention)
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Beetroot Shot | Data is for all participants following consumption of 1x70ml concentrated NO-3 shot of rich beetroot juice (~7mmol nitrate) (Beet It, James White Drinks Ltd, Ipswich, UK). |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr Jamie Macdonald | Bangor University | +441248383272 | j.h.macdonald@bangor.ac.uk |
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| ID | Term |
|---|---|
| D000860 | Hypoxia |
| ID | Term |
|---|---|
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Placebo shot then beetroot shot | Dietary Supplement | Placebo shot, four day wash out, then beetroot shot |
|
| NOT COMPLETED |
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| NOT COMPLETED |
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| years |
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| Sex: Female, Male | Count of Participants | Participants |
|
| Ethnicity (NIH/OMB) | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
|
|
| 0 |
| 10 |
| 0 |
| 10 |
| 0 |
| 10 |
| EG001 | Placebo Shot | Data is for all participants following consumption of 1x70ml nitrate-depleted beetroot shot (~0.003mmol of nitrate)(Beet It, James White Drinks Ltd, Ipswich, UK). | 0 | 10 | 0 | 10 | 0 | 10 |
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