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| Name | Class |
|---|---|
| Fund for Scientific Research, Flanders, Belgium | OTHER |
| Funds for Research in Ophthalmology, Belgium | UNKNOWN |
| Mieke Perdaens fund for Eye Research | UNKNOWN |
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The purpose of this study is to gain further insights into the molecular pathogenesis of Fuchs' endothelial corneal dystrophy (FECD), to identify targets for potential specific drug therapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| late-onset FECD | tissue samples from patients with late-onset Fuchs' endothelial corneal dystrophy (FECD) |
| |
| normal control | tissue samples from patients with normal corneas |
| |
| non-FECD edematous control | tissue samples from patients with corneal edema but without FECD |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| cytokine levels | dosage of cytokine levels in aqueous humour (exploratory, non-interventional study) | at time of prelevation (once, no intervention) |
| gene expression levels | microarray expression analysis, reverse transcriptase - quantitative polymerase chain reaction (RT-qPCR), RNA-sequencing (exploratory, non-interventional study) | at time of prelevation (once, no intervention) |
| protein content | immunohistochemistry and immunofluorescence | at time of prelevation (once, no intervention) |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with Fuchs' Endothelial Corneal Dystrophy (FECD), normal control patients, and patients with non-Fuchs edematous corneas; in university hospital setting.
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| Name | Affiliation | Role |
|---|---|---|
| Joost J van den Oord, MD, PhD | KU Leuven | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Translational Cell and Tissue Research - campus Sint-Raf - UZ Leuven | Leuven | 3000 | Belgium |
MEA and RT-qPCR data have been deposited in NCBI's Gene Expression Omnibus and are accessible through the Gene Expression Omnibus Series accession number GSE75676.
Data already available.
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| ID | Term |
|---|---|
| D005642 | Fuchs' Endothelial Dystrophy |
| ID | Term |
|---|---|
| D003317 | Corneal Dystrophies, Hereditary |
| D003316 | Corneal Diseases |
| D005128 | Eye Diseases |
| D015785 | Eye Diseases, Hereditary |
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Non-interventional study on corneal endothelium, anterior eye chamber fluid and paraffin-embedded corneal tissue, using molecular techniques to identify and characterise the molecular players involved in the pathogenesis of FECD.
| D030342 |
| Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |