The objectives of this study are to assess short term efficacy and safety of of topical preparation of essential oil extracted from ZINGIBER CASSUMUNAR ROXB in patients suffering from osteoarthritic pain

Inclusion Criteria:

• Diagnosis: osteoarthritis of the knee at least on side with standard radiologic method within 6 weeks (Kellgren-Lawrence radiographic grading scale at least 1)
• Pain visual analog scale at rest at least 40 mm
• No previous analgesic treatment or receiving stable dose of analgesic drugs at least 2 weeks. If previously treated with antidepressants, glucosamine, chondroitin or diacerein, dosage should be stable for at least 3 months.
• Agree to attain non-pharmacologic treatment as prior to participate the study

Exclusion Criteria:

• having an open wound or abnormal skin at site of application
• having diagnose with other chronic arthritis such as rheumatoid arthritis
• history of allergy to the extraction of Zingiber cassumunar Roxb
• pregnancy or breastfeeding