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The goal of the study is to determine the effect of different doses of caffeine on intraocular pressure. We hypothesized that higher dosage of caffeine would increase intraocular pressure more than lower doses.
Eligible subjects will be randomized into three groups:
Intraocular pressure will be measured at 0, 30, 60 and 90 minutes after coffee intake.
decaffeinated coffee contains 0.5-2 mg of caffeine regular dose coffee contains 91.8 mg of caffeine high dose coffee contains 144 mg of caffeine
all three groups' intraocular pressure will be measured with the Goldmann applanation tonometer at 4 timepoints:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group1: Decaffeinated coffee | Sham Comparator | contains 0.5-2 mg of caffeine |
|
| Group2: regular dose coffee | Active Comparator | contains 91.8 mg of caffeine |
|
| Group3: high dose coffee | Active Comparator | contains 144 mg of caffeine |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| decaffeinated coffee | Other | contains caffeine 0.5-2 mg |
| |
| Measure | Description | Time Frame |
|---|---|---|
| change from baseline in intraocular pressure (mmHg)after caffeine intake | intraocular pressure measured at 4 timepoints:
| 0, 30 minutes, 60 minutes, 90 minutes post-caffeine intake |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Damrong Wiwatwongwana, M.D. | Contact | 6653945512 | 5515 | samseeha@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Damrong Wiwatwongwana, M.D. | Chiang Mai University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chiang Mai University Hospital | Recruiting | Muang | Chiang Mai | 50200 | Thailand |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Feb 4, 2015 | |
| Reset | Feb 19, 2015 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Feb 4, 2015 | Feb 19, 2015 |
| ID | Term |
|---|---|
| D003069 | Coffee |
| ID | Term |
|---|---|
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
| D001628 | Beverages |
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| regular dose coffee |
| Other |
contains 91.8 mg of caffeine |
|
| high dose coffee | Other | contains 144 mg of caffeine |
|
| D000066888 |
| Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |