The purpose of this trial is to clarify the impact of lactobacillus preparation on the incidence of diarrhea in ICU-admitted patients.

Almost all patients in ICU are treated with antibiotics for the effective control of various infections. However, antibiotics-associated diarrhea is another matter of concern. Many previous studies were proved that the use of probiotic lactobacillus preparation can reduce antibiotics-associated diarrhea in ward-admitted patients. In this study, we are planning to perform a similar study in severely ill patients in ICU.

Inclusion Criteria:

• All patients admitted in intensive care unit
• Age more than 19

Exclusion Criteria:

• Diarrhea occurence within 1 week of ICU admission
• Recent history of probiotics use (within 1 month)
• GI obstruction
• History of abnormal symptoms and sign for the probiotics use (rash, edema, sepsis, etc.)
• immunocompromized patients