Measuring Corneal Cells With Specular Microscopy

Specular Photomicrograpic Assessment of the Effect of Anti-VEGF Intravitreal Injections on Corneal Thickness and Endothelial Cell Density and Morphology

Assess changes in the corneal cell count using Specular Microscopy following tretments with Anti-VEGF injections

Patients with active Wet AMD often receive intraocular Anti-VEGF injections such as Macugen, Lucentis and Avastin on a monthly basis for an extended period of time. While these medications are very effective at controlling the Choroidal Neovascularization associated with this disease, the impact of monthly intravigtreal Anti-VEGF injections on the viability of corneal endothelial cells has yet to be fully characterized. The availability of CESM as a diagnostic test that can be performed quickly and painlessly in the clinic offers a method of tracking corneal endothelial cell count in this patient population.

Inclusion Criteria:

• Wet Age-related Macular Degeneration
• Receiving monthly intraocular injections of Anti-VEGF medication for at least 3 months
• Age greater than 50 years of age

Exclusion Criteria:

• experiences adverse events