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| Name | Class |
|---|---|
| Nutreva S.A.S. | UNKNOWN |
| Foundation Child Care - FAN | OTHER |
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Acute respiratory infection and acute diarrhea are among the most prevalent diseases of childhood increase the burden of morbidity and mortality in children under 5 years.
Among the possible strategies for its prevention is important to count on good nutritional status for use in developing a good immune response to infections. Zinc deficiency has been shown to favor the development of infections and has been considered a real public health problem.
Within the zinc compounds used are zinc amino acid chelate and zinc sulphate, the first that has shown evidence of being better absorbed and tolerated.
We propose a study showing the effectiveness of zinc amino acid chelate and zinc sulphate in the prevention of acute diarrheal disease and acute respiratory infection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Zinc sulphate | Active Comparator | Preschool children healthy enrolled in FAN Foundation of Medellin, which will be supplied with zinc sulphate |
|
| Zinc Amino Acid Chelate | Experimental | Preschool children healthy enrolled in FAN Foundation of Medellin , which will be supplied with zinc amino acid chelate |
|
| Milk without fortification | Placebo Comparator | Milk without zinc |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Zinc sulfate as dietary supplementation | Dietary Supplement | Zinc sulfate as dietary supplementation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence acute diarrheal disease and acute respiratory infection | Preschool children will drink fortified milk with zinc amino acid chelate, zinc sulfate or milk without fortification. Fortnightly monitoring will be investigating the presence of infection (acute diarrheal disease and respiratory infections). Supervision and monitoring will be carried out for four months. | Up to 16 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Adverse reaction | The caregiver recorded daily if the child had an adverse reaction such as abdominal pain, nausea and vomiting. | Fortnightly. During 4 months of intervention |
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Inclusion Criteria:
Children who
Exclusion Criteria:
Children who
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| Name | Affiliation | Role |
|---|---|---|
| Liliana LM Montoya, Master | CES University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CES University | MedellÃn | Antioquia | Colombia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24967861 | Derived | Sanchez J, Villada OA, Rojas ML, Montoya L, Diaz A, Vargas C, Chica J, Herrera AA. [Effect of zinc amino acid chelate and zinc sulfate in the incidence of respiratory infection and diarrhea among preschool children in child daycare centers]. Biomedica. 2014 Jan-Mar;34(1):79-91. doi: 10.1590/S0120-41572014000100011. Spanish. |
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| ID | Term |
|---|---|
| D003967 | Diarrhea |
| ID | Term |
|---|---|
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D019287 | Zinc Sulfate |
| D019587 | Dietary Supplements |
| D008892 | Milk |
| D015032 | Zinc |
| ID | Term |
|---|---|
| D013431 | Sulfates |
| D013464 | Sulfuric Acids |
| D013456 | Sulfur Acids |
| D013457 | Sulfur Compounds |
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| Zinc amino acid chelate as dietary supplementation | Dietary Supplement | Zinc amino acid chelate as dietary supplementation |
|
| Milk without fortification without zinc | Dietary Supplement | Milk without fortification |
|
|
| D007287 |
| Inorganic Chemicals |
| D017967 | Zinc Compounds |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |
| D001628 | Beverages |
| D003611 | Dairy Products |
| D019216 | Metals, Heavy |
| D004602 | Elements |
| D028561 | Transition Elements |
| D008670 | Metals |