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| Name | Class |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | NIH |
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Two - four 6MWT performed according to ATS standards. Each walk however had specifically altered wording and coaching performed in random order to determine differences in outcomes. One walk was done in the standard ATS fashion. One was done coaching to walk as fast as the patient can walk. One was coached to walk at the patients normal walking pace. One was coached to walk at the patient's leisure walking pace.
Alternate 6MWT where subjects will be asked to walk as fast as they can, walk as normal as they can and walk leisurely as they can in 6 minutes compared to standard of care 6MWT which is walk as far as you can in 6 minutes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Alternative six minute walk test | Active Comparator | Subjects will be given the following instructions
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| Standard six minute walk test | Placebo Comparator | Subjects will be given the following instruction 1. walk as far as they can in 6 minutes |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| alternative six minute walk test | Procedure | Alternate instructions will be given Subjects will
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| Measure | Description | Time Frame |
|---|---|---|
| distance meters | this is an ongoing study of same day testing of 2-4 six minute walk tests, each with different instructions, to determine the impact of alternative instruction on outcome of the test | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| oxygen saturation | assessed as an outcome of variable instruction given in different six minute walk tests performed in random order on the same day | 1 day |
| dyspnea score | assessed as an outcome of variable instruction given in different six minute |
| Measure | Description | Time Frame |
|---|---|---|
| heart rate recovery at one minute | assessed as an outcome of variable instruction given in different six minute | 1 day |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Steven D Nathan, MD | Inova Advanced Lung Disease and Transplant Program | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Inova Advanced Lung Disease and Transplant Program | Falls Church | Virginia | 22042 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23975232 | Derived | Weir NA, Brown AW, Shlobin OA, Smith MA, Reffett T, Battle E, Ahmad S, Nathan SD. The influence of alternative instruction on 6-min walk test distance. Chest. 2013 Dec;144(6):1900-1905. doi: 10.1378/chest.13-0287. |
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We found that when the instruction was given to walk as fast as they can in six minutes, the distance was statistically greater than when the instruction was to walk as far as they can in six minutes. THe other instructions given yielded no difference in outcome. Other measures such are heart rate, Borg dyspnea score and saturation were not as statistically significant.
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| ID | Term |
|---|---|
| D017563 | Lung Diseases, Interstitial |
| D054990 | Idiopathic Pulmonary Fibrosis |
| D000081029 | Pulmonary Arterial Hypertension |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D011658 | Pulmonary Fibrosis |
| D006976 | Hypertension, Pulmonary |
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| ID | Term |
|---|---|
| D009154 | Mutation |
| ID | Term |
|---|---|
| D014644 | Genetic Variation |
| D055614 | Genetic Phenomena |
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| Standard six minute walk test | Procedure | Subjects will walk as far as they can in 6 minutes |
|
|
| 1 day |
| heart rate response | assessed as an outcome of variable instruction given in different six minute | 1 day |