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| Name | Class |
|---|---|
| Thai Red Cross AIDS Research Centre | OTHER |
| Chulalongkorn University | OTHER |
| SEARCH Research Foundation | OTHER |
| We Understand Group |
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This study will assess the prevalence of HPV infection in perinatally HIV-infected adolescents, intraepithelial neoplasia, and E6E7 biomarker at cervical and anal sites.
Human Papillomavirus (HPV) is the most common sexually transmitted disease and it causes cervical and anal cancer. Prevalence and incidence of HPV infection among young adults who are sexually experienced is high. No data exist for HIV-positive adolescents in regards to HPV infection, cervical and anal intraepithelial neoplasia. This study will compare the prevalence of HPV infection, intraepithelial neoplasia and E6/E7 biomarker at cervical and anal sites among perinatally HIV-infected adolescents, behaviorally HIV-infected adolescents, and HIV-negative adolescents.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Perinatally HIV-infected adolescents | Perinatally HIV-infected adolescents | ||
| behaviorally HIV-infected adolescents | behaviorally HIV-infected adolescents | ||
| HIV negative adolescents | HIV negative adolescents |
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| Measure | Description | Time Frame |
|---|---|---|
| HPV infection | Prevalence of cervical and anal HPV infection and of oncogenic subtypes, among perinatally HIV-infected adolescents, behaviorally HIV-infected adolescents, and HIv-negative adolescents | 48 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| intraepithelial neoplasia | Prevalence of intraepithelial neoplasia among the three study groups and in male and female subjects | 48 weeks |
| E6/E7 | Prevalence of detected E6/E7 biomarker among the tree study groups and in male and female subjects. Correlation between detected E6/E7 and presence of HPV infection and/or intraepithelial neoplasia Association between HAART use, CD4 counts, plasma HIV RNA level and HIV clinical staging with HPV infection, intraepithelial neoplasia and E6/E7 detection |
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Inclusion Criteria:
Exclusion Criteria:
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A total of 60 sexually active adolescents (perinatally and behaviorally HIV-infected adolescents, HIV negative adolescents) aged 12-24 will be recruited from the HIV-NAT and TRC Anonymous Clinic
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| Name | Affiliation | Role |
|---|---|---|
| Jintanat Ananworanich, MD, PhD | The HIV Netherlands Australia Thailand Research Collaboration | Principal Investigator |
| Nittaya Phanuphak, MD | Thai Red Cross AIDS Research Centre | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Pediatrics, Chulalongkorn University | Bangkok | 10330 | Thailand | |||
| HIV-NAT |
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| Label | URL |
|---|---|
| HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT)'s website | View source |
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| ID | Term |
|---|---|
| D030361 | Papillomavirus Infections |
| D002278 | Carcinoma in Situ |
| ID | Term |
|---|---|
| D015229 | Sexually Transmitted Diseases, Viral |
| D012749 | Sexually Transmitted Diseases |
| D003141 | Communicable Diseases |
| D007239 | Infections |
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| UNKNOWN |
| TREAT Asia | UNKNOWN |
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Cervical and anal pap smears specimens will be used for HPV typing. Blood will be collected for STI and immune response to HPV/HIV testing
| 48 weeks |
| HPV vaccine | Proportion of adolescents who would benefit from the current preventive vaccine (i.e. those who have not been infected with oncogenic HPV subtypes 16 and 18) | 48 weeks |
| Bangkok |
| 10330 |
| Thailand |
| Thai Red Cross - Anonymous Clinc | Bangkok | 10330 | Thailand |
| D004266 | DNA Virus Infections |
| D014777 | Virus Diseases |
| D014412 | Tumor Virus Infections |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |