Intralipid infusion can improve the outcome in NK cells positive females with history of recurrent miscarriages undergoing IVF/ICSI cycles.

Inclusion Criteria:

• Couples with unexplained secondary infertility
• Three or more prior consecutive clinical miscarriages after either spontaneous pregnancy or after IVF/ICSI.
• Elevated natural killer (NK) cells CD16, CD56 and cells with both CD16/CD56 >12%.

Exclusion Criteria:

• Age above forty years old.
• Antiphospholipid syndrome (lupus anticoagulant and/or anticardiolipin antibodies [IgG or IgM]); other recognised thrombophilic conditions (testing according to usual clinic practice).
• Intrauterine abnormalities (as assessed by ultrasound, hysterosonography, hysterosalpingogram, or hysteroscopy).
• Abnormal parental karyotype.
• Other identifiable causes of recurrent miscarriages (tests initiated only if clinically indicated) e.g., diabetes, thyroid disease and systemic lupus erythematosus (SLE).
• Disturbances of normal fat metabolism such as pathologic hyperlipemia
• Allergic to it; or to eggs, soybean oil, or safflower oil.
• Severe liver disease, kidney disease, lung disease, anemia, blood clotting disorder.