Tacrolimus/Methotrexate Versus Cyclosporine/Methotrexate for Prophylaxis of Graft Versus Host Disease

Tacrolimus/Methotrexate Versus Cyclosporine/Methotrexate for Prophylaxis of Graft Versus Host Disease in Paediatric Patients

This study aims to compare efficacy and safety of tacrolimus/methotrexate with cyclosporine/methotrexate for graft versus host disease prophylaxis in paediatric allogeneic hematopoietic stem cell transplantation patients.

Inclusion Criteria:

• Diagnosis of hematological malignancy
• Age under 18 years old
• Serum bilirubin less than 1.5 X upper limit of normal
• Aspartate transaminase, Alanine transaminase less than 2.5 X upper limit of normal
• Alkaline phosphatase less than 2.5 X upper limit of normal
• Serum creatinine less than 1.5 X upper limit of normal
• Agrees to participate, and informed consent signed

Exclusion Criteria:

• Evidence of HIV infection
• Documented uncontrolled disease (infections)
• Prior transplantation (hematopoietic stem cell or solid organs)