Polymorphism of beta2-adrenoceptor and Regular Use of Formoterol in Asthma

Polymorphism of beta2-adrenoceptor and Regular Use of Formoterol in Asthma: Preliminary Results

Polymorphism at codon 16 of the beta2-adrenoceptor (beta2-AR) affects the responsiveness to salmeterol in asthmatics. Data concerning formoterol are more controversial in literature. The aim of this study was to verify whether homozygote for arginine-16 (ArgArg16) and homozygote for glycine-16 (GlyGly16) genotypes differently influence the long-term responsiveness to formoterol.

Inclusion Criteria:

• Mild to moderate asthma
• Stable clinical conditions

Exclusion Criteria:

• Smokers
• Current therapy with oral steroids
• Exacerbations within the past 3 months