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Amyotrophic Lateral Sclerosis (ALS) is a progressive fatal neurodegenerative disease affecting motor neurons. Early diagnosis is essential for the success of clinical trials and objective biomarkers are needed for monitoring disease progression. Nerve and muscle ultrasound may provide this information.
This study will collect pilot data to evaluate the value of muscle and nerve ultrasound to identify and monitor disease progression in ALS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control Group | No intervention to be performed. | ||
| Ultrasound Group | All will receive nerve and muscle ultrasound. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ultrasound of nerve and muscle | Other | Ultrasound of 6 muscles and 2 nerves will be performed. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Abnormalities at onset: Ultrasound vs. Electromyography | Ultrasound measures will be compared to electromyography measures at the patient's initial assessment. The number of abnormal muscles will be counted using each technique and analyzed to determine if one test is superior. | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Ultrasound Predicting Outcome at 1 year | The initial ultrasound measures and patient outcomes, as measured by standard validated scales, will be assessed at periodic intervals for one year. Analysis will be performed to determine if ultrasound measures can predict the clinical course. | 1.5 years |
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Inclusion Criteria:
Exclusion Criteria:
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All patients referred to the electromyography laboratory for ALS.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Duke University Medical Center | Durham | North Carolina | 27710 | United States |
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