The purpose of this study is to evaluate th safety and efficacy of one-daily topical application of CLS001 low, mid and high dose compared to vehicle gel in subjects with papulopustular rosacea.

Inclusion Criteria:

• diagnosis of papulopustular rosacea (at least 15 lesions)

Exclusion Criteria:

• nodular rosacea or subtype 3
• clinically significant abnormal findings that would interfere with study objectives