Incretin Effect on the Immunological Phenotype

Pilot Study on Incretin Effect on the Immunological Phenotype in Healthy Subjects and in Type 1 Diabetic Subjects

Assessment of the effect of incretin based therapies (Liraglutide and Saxagliptin) on immune cells in healthy subjects and patients with type 1 diabetes

Assessment of immunological effects of Saxagliptin and Liraglutide on immune cells of the peripheral blood.

Inclusion Criteria:

-healthy subjects or patients with type 1 diabetes

Exclusion Criteria:

• pregnancy
• treatment with GLP-1-Analoga (Liraglutide, Exenatide)
• treatment with DPP4-inhibitor (Sitagliptin, Vildagliptin, Saxagliptin)
• chronic disease including a long-term medication over 4 weeks per year (except type 1 diabetes)