Intervention to Promote Changes of Healthy Lifestyle (Physical Activity and Nutrition) During Gestation

Intervention en Changement Des Habitudes de Vie Par l'Activité Physique et un Support Nutritionnel Durant la Grossesse en Estrie

The purpose of this study are:

• Assess the impact of an intervention to the adoption of healthy lifestyles among pregnant women at high risk of gestational diabetes mellitus on:

  • weight gain in pregnancy
  • the levels of maternal and fetal adipokines and
  • glycemic control maternal and fetal.

• Determine whether the adoption of healthy lifestyles in pregnancy is associated with epigenetic changes that influence the levels of adipokines and glucose regulation during pregnancy and in newborns.

Inclusion Criteria:

• be aged ≥ 18 years,
• have a pre-pregnancy BMI ≥ 25 kg/m2,
• be at risk of developing a gestational diabetes mellitus (a history of gestational diabetes mellitus or glucose 1 hour post-50g > 7.1 mmol/L.

Exclusion Criteria:

• Pre-pregnancy diabetes detected in the first trimester (A1c > 6.5%, fasting glucose > 7.0 mmol/L, random blood glucose> 11.1 mmol/L, glucose > 10.3 mmol/L 1 hour post-50g)
• twin pregnancy
• taking medications that can affect blood sugar or weight,
• practice ≥ 150 minutes of physical activity per week
• against formal-indication for physical activity.