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This study objective is to evaluate the change in mitochondrial uncoupling protein 2 (UCP2) mRNA expression as function of thyroid activity (TSH, T3 and Free T4).
Blood will be drown before thyroidectomy, 2 weeks after the operation and 3-4 month after the operation.
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| Measure | Description | Time Frame |
|---|---|---|
| Changes in UCP2 mRNA concentrations. | The difference between the result at two weeks and four months compare to base line. | Base line (before opporation), 2 weeks after opporation and for after opporation. |
| Measure | Description | Time Frame |
|---|---|---|
| Weight | Approximately 4 months | |
| Resting energy expenditure | Approximatly 4 months |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who were diagnosed with thyroid carcinoma and are going throgh total thyroidectomy and recive a thyroid replacement therapy.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nachum Vaisman, M.D. | Contact | 972-3-6974807 | vaisman@tasmc.health.gov.il |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tel Aviv Sourasky Medical Center | Recruiting | Tel Aviv | 64239 | Israel |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 11427693 | Background | Yen PM. Physiological and molecular basis of thyroid hormone action. Physiol Rev. 2001 Jul;81(3):1097-142. doi: 10.1152/physrev.2001.81.3.1097. | |
| 203955 | Background | Schwartz HL, Oppenheimer JH. Physiologic and biochemical actions of thyroid hormone. Pharmacol Ther B. 1978;3(3):349-76. doi: 10.1016/s0306-039x(78)80002-6. No abstract available. |
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| ID | Term |
|---|---|
| D013964 | Thyroid Neoplasms |
| ID | Term |
|---|---|
| D004701 | Endocrine Gland Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D006258 | Head and Neck Neoplasms |
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Whole blood for UCP2 mRNA
| 16098826 | Background | Brand MD, Esteves TC. Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3. Cell Metab. 2005 Aug;2(2):85-93. doi: 10.1016/j.cmet.2005.06.002. |
| 6320232 | Background | Nicholls DG, Locke RM. Thermogenic mechanisms in brown fat. Physiol Rev. 1984 Jan;64(1):1-64. doi: 10.1152/physrev.1984.64.1.1. No abstract available. |
| 20427509 | Background | Gjedde S, Gormsen LC, Riis AL, Jorgensen JO, Rungby J, Moller N, Weeke J, Pedersen SB. Reduced expression of uncoupling protein 2 in adipose tissue in patients with hypothyroidism. J Clin Endocrinol Metab. 2010 Jul;95(7):3537-41. doi: 10.1210/jc.2009-0907. Epub 2010 Apr 28. |
| D004700 |
| Endocrine System Diseases |
| D013959 | Thyroid Diseases |