Vitamin D Supplementation to Obese Chinese Males

Health Effect of Oral Vitamin D Supplementation on Obese Chinese Males

Hypothesis: Oral Supplementation of Vitamin D can Reduce Hypersecretion of Parathyroid Hormone and Insulin Resistance in Obese Chinese Males.

Protocol: Weekly oral supplementation of 50,000 IU vitamin D (cholecalciferol) or eight weeks to the obese males compared with the normal-weight males. Index measures were conducted at baseline and endpoint.

Inclusion Criteria:

• body mass index (BMI) ≥ 28kg/m2 or 18.5 ≤ BMI < 24 (kg/m2)
• non vegetarian Han Chinese and did not smoke, drink, nor take vitamin D supplements for > 2 y
• fasting serum glucose < 7.0 mmol/L
• serum glucose of 2 hr after 75 g oral glucose loading < 11.1 mmol/L
• normal functioning of liver and kidney evaluated by alkaline phosphatase, aspartate aminotransferase, creatinine, and uric acid

Exclusion Criteria:

• not match the above inclusion criteria
• diagnosed as having any organic diseases were excluded