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The purpose of this study is to reveal the specific effects of computer-aided cognitive training on cerebral reorganization in schizophrenia
Impairment in cognitive functions is one of the main symptoms in schizophrenia and is currently one of the challenges in the treatment of the disease. In this study we compare effects of two computer-aided training programs. One focused on auditory perception and processing as a basic ability underlying higher order information processing. The other training focus on facial affect discrimination and working memory. Both trainings are computer-aided and time-intensive, including up to twenty sessions within four weeks.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Auditiory verbal discrimination training | Experimental | Brain Fitness & Brain Training- Posit Science |
|
| Facial affect discrimination training | Experimental | Behavioral: Facial Affect Training- FAT |
|
| Treatment as usual | Active Comparator | standard treatment/rehabilitation protocol of schizophrenia ward |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Brain Fitness & Brain Training- Posit Science | Behavioral | Computer aided cognitive program designed for intensive training of auditory perception, memory and attention |
|
| Measure | Description | Time Frame |
|---|---|---|
| change from baseline at post-intervention (4-weeks) and 3-months in each to the primary outcome measures: neuropsychological test scores (MCCB), MEG alpha oscillations | baseline, post-intervention (after 4 weeks), 3-months follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| change from baseline in global functioning (GAF score) at 4 weeks and 3 months | baseline, post-intervention, 3-months follow-up |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Brigitte Rockstroh, Prof. Dr. | University Konstanz | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Konstanz | Konstanz | Baden-Wurttemberg | 78464 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25379427 | Background | Popova P, Popov TG, Wienbruch C, Carolus AM, Miller GA, Rockstroh BS. Changing facial affect recognition in schizophrenia: effects of training on brain dynamics. Neuroimage Clin. 2014 Sep 4;6:156-65. doi: 10.1016/j.nicl.2014.08.026. eCollection 2014. |
| Label | URL |
|---|---|
| Brain Training Software | View source |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D013812 | Therapeutics |
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| Facial Affect Training- FAT | Behavioral | Computer-aided cognitive program designed for intensive training of facial affect discrimination, memory and attention |
|
| Treatment as usual | Behavioral | standard treatment protocol of schizophrenia ward |
|