Not provided
Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| S51516 | Other Identifier | Ethical Committee Univ.Hospital |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of the study was to investigate whether functional MRI imaging (diffusion weighted imaging) is useful for monitoring the therapeutic response of bone sarcomas in children and young adults. All patients will be scanned before, during and after chemotherapy. The findings on MRI will be correlated with histological finding after surgery.
Second purpose : to define apparent diffusion coefficient value of the bone sarcoma.
Third purpose : to try define prognostic factors, to investigate if there is a correlation between early treatment response and outcome.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Osteosarcoma | All patients with Osteosarcoma), proven by surgical biopsy and histopathology. All included patients will be treated by chemotherapy (EURAMOS protocol) An MRI will be performed before, during and post-treatment |
| |
| Ewing Sarcoma | All patients with proven diagnosis of Ewing sarcoma, proven by surgical biopsy and histopathology. All included patients will be treated by chemotherapy (EURO-EWING protocol) An MRI will be performed in all included patients before, during and after the chemotherapy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MRI | Other | MRI exam will be performed in all patients included in the study. The patients will be treated by chemotherapy, defined in the EURO-EWING or EURAMOS protocol. The MR findings will not have any impact on the treatment. |
| Measure | Description | Time Frame |
|---|---|---|
| tumor necrosis - therapy response | correlation of MRI findings with clinical findings during chemotherapy correlation of diffusion weighted MRI and histopathology results after surgical resection. Calculation of apparent diffusion coefficient : is it a valuable parameter? | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Prognosis and outcome | Is there a correlation between early treatment response and outcome? Is diffusion weighted MRI able to predict outcome of the patient (prognostic factor)? | 2 years |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
patients with Ewing sarcoma or Osteosarcoma, proven by biopsy and histolopathology.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Steven Pans, MD | Contact | 3216340505 | steven.pans@uzleuven.be |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospitals Leuven | Recruiting | Leuven | 3000 | Belgium |
Not provided
| ID | Term |
|---|---|
| D012512 | Sarcoma, Ewing |
| D012516 | Osteosarcoma |
| ID | Term |
|---|---|
| D018213 | Neoplasms, Bone Tissue |
| D009372 | Neoplasms, Connective Tissue |
| D018204 | Neoplasms, Connective and Soft Tissue |
| D009370 | Neoplasms by Histologic Type |
Not provided
Not provided
Not provided
Not provided
Not provided
| D009369 | Neoplasms |
| D012509 | Sarcoma |