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| Name | Class |
|---|---|
| Canadian Cancer Society (CCS) | OTHER |
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Cancer-related fatigue is one of the most common and distressing symptoms associated with a cancer diagnosis.Fatigue related to cancer often appears before a diagnosis, worsens during treatment, and lasts for years after treatment in up to 35% of patients. Despite the long-term effects of cancer-related fatigue, the treatment options available are not always appropriate or helpful for all patients.Light therapy is an effective treatment for other disorders related to fatigue. The purpose of the study is to investigate the role of light therapy on quality of life, sleep patterns, and physical measures of immune function and stress hormones in individuals with post-treatment cancer-related fatigue.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bright White Light | Experimental | Bright white light exposure every morning for 30 minutes for 28 consecutive days |
|
| Dim Red Light | Active Comparator | Dim red light exposure every morning for 30 minutes for 28 consecutive days |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bright white light | Device |
|
| |
| Measure | Description | Time Frame |
|---|---|---|
| Change in fatigue symptoms from baseline to post-treatment | Baseline, after each treatment week (each week for 4 weeks), and at week 5 |
| Measure | Description | Time Frame |
|---|---|---|
| Change in objective measures of sleep using wrist actigraphy from baseline to post-treatment | Baseline (for 7 days), week 5 (for 7 days) | |
| Change in subjective measures of sleep using sleep diaries from baseline to post-treatment | Baseline (for 7 days), week 5 (for 7 days) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Tavis S Campbell, PhD | University of Calgary | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Behavioural Medicine Laboratory | Calgary | Alberta | T2N 1N4 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33070045 | Derived | Johnson JA, Subnis U, Carlson LE, Garland SN, Santos-Iglesias P, Piedalue KL, Deleemans JM, Campbell TS. Effects of a light therapy intervention on diurnal salivary cortisol in fatigued cancer survivors: A secondary analysis of a randomized controlled trial. J Psychosom Res. 2020 Dec;139:110266. doi: 10.1016/j.jpsychores.2020.110266. Epub 2020 Oct 6. |
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
| D005221 | Fatigue |
| ID | Term |
|---|---|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D014467 | Ultraviolet Therapy |
| ID | Term |
|---|---|
| D010789 | Phototherapy |
| D013812 | Therapeutics |
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| Dim red light |
| Device |
|
|
| Change in Pittsburgh Sleep Quality Index scores from baseline to post-treatment | Baseline, week 5 |
| Change in Profile of Mood States scores from baseline to post-treatment | Baseline, week 5 |
| Change in Functional Assessment of Cancer Therapy (General & Fatigue) scores from baseline to post-treatment | Baseline, week 5 |
| Change in salivary cortisol from baseline to post-treatment | Baseline (for 3 days), week 5 (for 3 days) |
| Change in inflammatory cytokines from baseline to post-treatment | Baseline, week 5 |
| Change in Insomnia Severity Index scores from baseline to post-treatment | Baseline, week 3, week 5 |