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The investigators' goal is to determine if certain tests of memory and attention, performed while sleepiness is induced by a single dose of lorazepam, can predict whether or not an individual is at risk for developing Alzheimer's disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| L/VL APOE e3/e4 carrier | Other | long and very long poly - T variants of TOMM40 and APOE e3/e4 carrier |
|
| L/S APOE e3/e4 carrier | Other | long and short poly - T variants of TOMM40 and APOE e3/e4 carrier |
|
| S/VL APOE e3/e3 carrier | Other | short and Very long poly - T variants of TOMM40 and APOE e3/e3 carrier |
|
| VL/VL APOE e3/e3 carrier | Other | Very long poly - T variants of TOMM40 and APOE e3/e3 carrier |
|
| S/S APOE e3/e3 carrier | Other | short poly - T variants of TOMM40 and APOE e3/e3 carrier |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| lorazepam | Drug | single dose of 1 mg lorazepam |
|
| Measure | Description | Time Frame |
|---|---|---|
| Groton Maze Learning Test (GMLT) score | The GMLT assesses visuospatial working memory, error monitoring, information processing speed, and short-term delayed recall for a complex hidden maze. Subjects are familiarized with the task during two untimed practice tests, and once the tester is confident that the subject understands the rules and can move easily around the grid, the timed test is administered. In each of the 5 successive trials of the GMLT exam, the subject is asked to learn to navigate his or her way around a 28-step maze that is hidden beneath a 10 x 10 grid of squares on the computer touch screen. For each trial, the time to completion, number of correct moves, number of wrong moves, and the number of perseverative errors are recorded. | baseline to 5 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Auditory Verbal Learning Test (AVLT) Long-term memory score | The AVLT assesses verbal memory | baseline to 5 hours |
| Two Back Test (TBK) | The TBK measures working memory |
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Inclusion criteria:
Exclusion criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Cynthia Stonnington, MD | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic | Scottsdale | Arizona | 85259 | United States |
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| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D008140 | Lorazepam |
| ID | Term |
|---|---|
| D001570 | Benzodiazepinones |
| D001569 | Benzodiazepines |
| D001552 | Benzazepines |
| D006574 | Heterocyclic Compounds, 2-Ring |
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|
| baseline to 5 hours |
| D024801 |
| Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D000072471 |
| Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |