The purpose of this research study is to determine the diurnal and nocturnal effects of Travoprost with SofZia (Travatan Z) on intraocular pressure and ocular perfusion pressure.

The investigators hypothesize that Travatan Z will significantly lower intraocular pressure and increase ocular perfusion pressure during both the diurnal and nocturnal period, during a 24-hour evaluation, compared to baseline. The investigators further hypothesize that the medication effects will persist at 72 hours after discontinuation of the drug.

Inclusion Criteria:

• Diagnosis of open-angle glaucoma or ocular hypertension, including pigment dispersion glaucoma and pseudoexfoliation glaucoma
• Age ≥ 18 or ≤ 90 years, of either gender, or any race/ethnicity

Exclusion Criteria:

• Females who are currently pregnant or planning to become pregnant, as determined by history during the study period
• Diagnosis of any other form of glaucoma other than open-angle
• Schaffer angle grade < 2 in either eye by gonioscopy
• Chronic, recurrent, or severe inflammatory eye disease
• Intraocular surgery within 6 months or laser within 3 months
• History of active, recurrent, or chronic ocular infection with the Herpes Simplex Virus
• History of cystoid macular edema
• Inability to safely discontinue all ocular medications for 4 weeks
• Patients who smoke or have irregular daily sleep patterns
• Patients who have started or changed glucocorticoids therapy in the last 3 months
• Patients who are currently undergoing medical marijuana therapy
• Any use of a non-FDA approved medication for glaucoma in the last 3 months

Patients diagnosed with open angle glaucoma or ocular hypertension